Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations

USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States

University of California Davis Comprehensive Cancer Center, Sacramento, California, United States

UCSF Medical Center-Mission Bay, San Francisco, California, United States

Kaiser Permanente Medical Center, Vallejo, California, United States

University of Colorado Health, Aurora, Colorado, United States

Illinois Cancer Specialists, Arlington Heights, Illinois, United States

University of Illinois Hospital and Health Sciences Systems, Chicago, Illinois, United States

Northwell Health/R.J. Zuckerberg Cancer Center, Lake Success, New York, United States

Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York, New York, United States

Ohio State University Hospitals, Columbus, Ohio, United States

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

Texas Oncology, Dallas, Texas, United States

The University of Texas MD Anderson Cancer Center, Houston, Texas, United States

University of Virginia, Charlottesville, Virginia, United States

Virginia Cancer Specialists, Fairfax, Virginia, United States

Shenandoah Oncology, P.C., Winchester, Virginia, United States

Swedish Cancer Institute, Edmonds, Washington, United States

Blacktown Cancer and Haematology Centre, Blacktown, New South Wales, Australia

Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia

GenesisCare North Shore Health Hub, St Leonards, New South Wales, Australia

Austin Health, Heidelberg, Victoria, Australia

Alberta Health Services, Tom Baker Cancer Centre, Calgary, Alberta, Canada

BC Cancer Vancouver Centre, Vancouver, British Columbia, Canada

The Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada

Sunnybrook Research Institute, Toronto, Ontario, Canada

Princess Margaret Cancer Centre - University Health Network, Toronto, Ontario, Canada

Hospices Civil de Lyon, Bron, Auvergne-Rhône-Alpes, France

Hospital Nord de Marseille, Marseille, Bouches-du-Rhone, France

Centre Francois Baclesse, Caen, Calvados, France

Hopital Larrey, Toulouse, Occitanie, France

Centre Leon-Berard, Lyon, France

Hopital Nord Guilaume-et-Rene-Laennec CHU de Nantes, Saint-Herblain, France

Insitut de Canderologie d I'Ouest, Saint-Herblain, France

Henry Dunant Hospital Center, Athens, Greece

University General Hospital Attikon - General Hospital of West Attica H AGIA VARVARA, Athens, Greece

Athens Medical Center S.A., European Interbalkan Medical Center, Thessaloniki, Greece

Thoracic General Hospital of Athens I Sotiria, Thessaloniki, Greece

Queen Mary Hospital, Hong Kong, Hong Kong, Hong Kong

Humanity and Health Clinical Trial Centre, Central, Hong Kong

SOC Oncologia Medica e dei Tumori Immuno-correlati, Aviano, Italy

Istituto Europeo di Oncologia (IEO), Milan, Italy

Aichi Cancer Center, Nagoya, Aichi-ken, Japan

Kurume University Hospital, Kurume-Shi, Fukuoka, Japan

National Hospital Organization Hokkaido Cancer Center, Sapporo, Hokkaido, Japan

Hyogo Cancer Center, Akashi-shi, Hyōgo, Japan

Miyagi Cancer Center, Natori-shi, Miyagi, Japan

Niigata Cancer Center Hospital, Niigata, Niigata, Japan

Kansai Medical University Hospital, Hirakata-shi, Osaka, Japan

Nippon Medical School Hospital, Bunkyo-ku, Tokyo, Japan

Tokyo Metropolitan Komagome Hospital, Bunkyō-Ku, Tokyo, Japan

National Cancer Center Hospital, Chuo-ku, Tokyo, Japan

OncoCar Cancer Centre, Petaling Jaya, Selangor, Malaysia

Hospital Kuala Lumpur, Kuala Lumpur, WP Kuala Lumpur, Malaysia

National Cancer Centre Singapore, Singapore, Singapore

Curie Oncology (Farrer), Singapore, Singapore

Tan Tok Seng Hospital, Singapore, Singapore

The Catholic University of Korea, St. Vincent's Hospital, Suwon, Gyeonggi-do, South Korea

Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, South Korea

Gachon University Gil Medical Center, Incheon, South Korea

Kyung Hee University Hospital, Seoul, South Korea

Kangbuk Samsung Hospital, Seoul, South Korea

Asan Medical Center, Seoul, South Korea

Samsung Medical Center, Seoul, South Korea

Hospital Universitari Son Espases, Palma, Balearic Islands, Spain

Hospital Clinic de Barcelona, Barcelona, Spain

Hospital QuironSalud Malaga, Málaga, Spain

Hospital Universitario Central de Asturias, Oviedo, Spain

Hospital Universitario y Politecnico La Fe, Valencia, Spain

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, Taiwan

Taichung Veterans General Hospital, Taichung, Taiwan

National Taiwan University Cancer Center, Taipei, Taiwan

Taipei Veterans General Hospital, Taipei, Taiwan

Mahidol University - Siriraj Hospital, Bangkoknoi, Bangkok, Thailand

Chulabhorn Hospital, Lak Si, Bangkok, Thailand

Prince of Songkla Hospital, Hat Yai, Changwat Songkhla, Thailand

University College London Hospitals NHS Foundation Trust, London, England, United Kingdom

The Christie NHS Foundation Trust, Manchester, England, United Kingdom

The Royal Marsden NHS Foundation Trust, London, United Kingdom