A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

City of Hope, Duarte, California, United States

City of Hope - Orange County Lennar Foundation Cancer Center, Irvine, California, United States

UC San Diego Moores Cancer Center, La Jolla, California, United States

UCSF Helen Diller Family CCC, San Francisco, California, United States

Sylvester Comprehensive Cancer Center, Miami, Florida, United States

Moffitt Cancer Center, Tampa, Florida, United States

Winship Cancer Institute of Emory University, Atlanta, Georgia, United States

City of Hope® Cancer Center Chicago, Zion, Illinois, United States

Barbara Ann Karmanos Cancer Institute, Detroit, Maine, United States

Washington University Siteman Cancer Center, St Louis, Missouri, United States

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States

New York Cancer & Blood Specialists, East Patchogue, New York, United States

Levine Cancer Institute, Charlotte, North Carolina, United States

Novant Health Cancer Institute, Charlotte, North Carolina, United States

University of Pennsylvania - Abramson Cancer Center, Philadelphia, Pennsylvania, United States

UPMC - Hillman Cancer Center, Pittsburgh, Pennsylvania, United States

Vanderbilt Breast Center at One Hundred Oaks, Nashville, Tennessee, United States

Texas Oncology (Worth) - USOR, Dallas, Texas, United States

University of Utah Huntsman Cancer Institute, Salt Lake City, Utah, United States

Virginia Oncology Associates (Norfolk) - USOR, Norfolk, Virginia, United States

St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia

Cancer Research SA, Adelaide, South Australia, Australia

Hospital do Cancer de Pernambuco - HCP, Recife, Pernambuco, Brazil

ONCOSITE Centro de Pesquisa Clínica Em Oncologia, Ijuí, Rio Grande do Sul, Brazil

Irmandade Da Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil

Hospital de Clinicas de Porto Alegre (HCPA) - PPDS, Porto Alegre, Rio Grande do Sul, Brazil

Instituto Do Câncer Do Estado de São Paulo Octávio Frias de Oliveira - ICESP, São Paulo, Brazil

Princess Margaret Hospital, Toronto, Ontario, Canada

Shandong Cancer Hospital, Jinan, SD, China

Fudan University Shanghai Cancer Center - Pudong Campus, Shanghai, Shanghai Municipality, China

Institut Jean Godinot, Reims, Champagne-Ardenne, France

Gustave Roussy, Villejuif, Val-de-Marne, France

Centre Francois Baclesse, Caen, France

Centre Oscar Lambret, Lille, France

Centre Eugene Marquis, Rennes, France

KEM - Evang. Huyssens-Stiftung Essen-Huttrop, Essen, North Rhine-Westphalia, Germany

Universitatsklinikum Hamburg-Eppendorf, Hamburg, Germany

IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Emilia-Romagna, Italy

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRST S.r.l - PPDS, Meldola, Emilia-Romagna, Italy

ASST degli Spedali Civili di Brescia - Spedali Civili di Brescia, Brescia, Lombardy, Italy

Ospedale San Raffaele S.r.l. - PPDS, Milan, Lombardy, Italy

Gangnam Severance Hospital, Yonsei University Health System, Seoul, Seoul Teugbyeolsi, South Korea

Seoul National University Bundang Hospital, Seongnam-si, South Korea

Seoul National University Hospital, Seoul, South Korea

Asan Medical Center., Seoul, South Korea

Severance Hospital, Yonsei University Health System, Seoul, South Korea

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea

Instituto de Investigacion Oncologica Vall dHebron (VHIO) - EPON, Barcelona, Spain

Hospital Beata Maria Ana, Madrid, Spain

Hospital General Universitario Gregorio Maranon, Madrid, Spain

Hospital Universitario 12 de Octubre, Madrid, Spain

Hospital Clinico Universitario de Valencia, Valencia, Spain