This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

Clearview Cancer Institute (Crestwood), Huntsville, Alabama, United States

Clearview Cancer Institute, Huntsville, Alabama, United States

Ironwood Cancer & Research Centers, Chandler, Arizona, United States

Ironwood Cancer & Research Centers, Gilbert, Arizona, United States

Ironwood Cancer & Research Centers, Glendale, Arizona, United States

Ironwood Cancer & Research Centers, Goodyear, Arizona, United States

Ironwood Cancer & Research Centers, Mesa, Arizona, United States

Ironwood Cancer & Research Centers, Mesa, Arizona, United States

Ironwood Cancer & Research Centers, Phoenix, Arizona, United States

Ironwood Cancer & Research Centers, Scottsdale, Arizona, United States

Highlands Oncology Group, PA, Fayetteville, Arkansas, United States

Highlands Oncology Group, PA, Rogers, Arkansas, United States

Highlands Oncology Group, PA, Springdale, Arkansas, United States

UCLA Hematology/Oncology - Alhambra, Alhambra, California, United States

UCLA Hematology/Oncology - Atascadero, Atascadero, California, United States

Cedars-Sinai Cancer Beverly Hills (drug treatment and dispensing location), Beverly Hills, California, United States

Cedars-Sinai Cancer Beverly Hills, Beverly Hills, California, United States

UCLA Hematology/Oncology - Beverly Hills, Beverly Hills, California, United States

UCLA Hematology/Oncology - Burbank, Burbank, California, United States

UCLA Hematology/Oncology - Encino, Encino, California, United States

UCLA Hematology/Oncology - Irvine, Irvine, California, United States

UCLA Hematology/Oncology - Laguna Hills, Laguna Hills, California, United States

Cedars-Sinai Cancer at Cedars-Sinai Medical Center, Los Angeles, California, United States

Ronald Reagan UCLA Medical Center - Drug Information Center, Los Angeles, California, United States

UCLA Department of Medicine - Hematology/Oncology, Los Angeles, California, United States

UCLA Hematology/Oncology, Los Angeles, California, United States

UCLA Hematology/Oncology - Marina del Rey, Marina del Rey, California, United States

UCLA Hematology/Oncology - Pasadena, Pasadena, California, United States

UCLA Hematology/Oncology - Porter Ranch, Porter Ranch, California, United States

UCLA Hematology/Oncology - San Luis Obispo, San Luis Obispo, California, United States

UCLA Hematology/Oncology - Santa Barbara, Santa Barbara, California, United States

UCLA Hematology/Oncology- Santa Monica, Santa Monica, California, United States

UCLA Hematology/Oncology - Torrance, Torrance, California, United States

UCLA Hematology/Oncology - Santa Clarita, Valencia, California, United States

UCLA Hematology/Oncology - Ventura, Ventura, California, United States

UCLA Hematology/Oncology - Westlake, Westlake Village, California, United States

AdventHealth Medical Group Urology of Denver, Denver, Colorado, United States

Cancer Care Specialists of Illinois, Decatur, Illinois, United States

Cancer Care Specialists of Illinois, O'Fallon, Illinois, United States

Michigan Institute of Urology, PC, Troy, Michigan, United States

MSK Basking Ridge, Basking Ridge, New Jersey, United States

MSK Monmouth, Middletown, New Jersey, United States

MSK Bergen, Montvale, New Jersey, United States

MSK Commack, Commack, New York, United States

MSKCC-Westchester (500 Westchester Ave.), Harrison, New York, United States

Memorial Sloan Kettering Cancer Center (IDS Pharmacy), Long Island City, New York, United States

Evelyn H. Lauder Breast and Imaging Center (BAIC)., New York, New York, United States

Memorial Sloan Kettering Cancer Center - Main Campus, New York, New York, United States

Sidney Kimmel Center for Prostate and Urological Cancers - Memorial Sloan Kettering Cancer Center, New York, New York, United States

University of Rochester Medical Center, Rochester, New York, United States

University of Rochester, Cancer Center Pharmacy (Investigational Product), Rochester, New York, United States

Montefiore Einstein Comprehensive Cancer Center, The Bronx, New York, United States

Montefiore Medical Center- Montefiore Medical Park, The Bronx, New York, United States

MSK Nassau., Uniondale, New York, United States

Duke Cancer Center Cary, Cary, North Carolina, United States

Duke University Medical Center (location of scans), Durham, North Carolina, United States

Duke University Medical Center - Duke Cancer Center, Durham, North Carolina, United States

Duke University Medical Center - Duke University Hospital (location of scans), Durham, North Carolina, United States

Duke University, Durham, North Carolina, United States

Duke Cancer Center Raleigh, Raleigh, North Carolina, United States

Duke Raleigh Hospital, Raleigh, North Carolina, United States

Duke Women's Cancer Care Raleigh (Pharmacy location and location of CT, MRI and Bone scan machines), Raleigh, North Carolina, United States

University Hospitals Seidman Cancer Center at UH Avon Health Center, Avon, Ohio, United States

TriState Urologic Services PSC Inc. dba The Urology Group, Cincinnati, Ohio, United States

University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States

University Hospitals Seidman Cancer Center at UH Mentor Health Center, Mentor, Ohio, United States

UH Minoff Health Center at Chagrin Highlands, Orange, Ohio, United States

The Centers for Advanced Urology, LLP d/b/a Keystone Urology Specialists, Lancaster, Pennsylvania, United States

Grand Strand Medical Center, Myrtle Beach, South Carolina, United States

Carolina Urologic Research Center, LLC, Myrtle Beach, South Carolina, United States

Parkway Surgery Center, Myrtle Beach, South Carolina, United States

The West Clinic, PLLC dba West Cancer Center, Germantown, Tennessee, United States

Urology Associates, P.C., Nashville, Tennessee, United States

University of Texas Southwestern Medical Center - Simmons Cancer Center, Dallas, Texas, United States

University of Texas Southwestern Medical Center - William P. Clements, Jr., University Hospital, Dallas, Texas, United States

University of Texas Southwestern Simmons Cancer Center - Redbird, Dallas, Texas, United States

University of Texas Southwestern Medical Center-Zale Lipshy University Hospital, Dallas, Texas, United States

University of Texas Southwestern Medical Center, Dallas, Texas, United States

University of Texas Southwestern Simmons Cancer Center - Fort Worth, Fort Worth, Texas, United States

US Oncology Investigational Product Center (IPC), Irving, Texas, United States

University of Texas Southwestern Simmons Cancer Center - Richardson/Plano, Richardson, Texas, United States

Huntsman Cancer Institute, Salt Lake City, Utah, United States

Blue Ridge Cancer Care, Blacksburg, Virginia, United States

Blue Ridge Cancer Care, Low Moor, Virginia, United States

Blue Ridge Cancer Care, Roanoke, Virginia, United States

Blue Ridge Cancer Care, Salem, Virginia, United States

Blue Ridge Cancer Care, Wytheville, Virginia, United States

Northwest Medical Specialties, PLLC, Bonney Lake, Washington, United States

Northwest Medical Specialties, PLLC, Federal Way, Washington, United States

Northwest Medical Specialties, PLLC, Gig Harbor, Washington, United States

Northwest Medical Specialties, PLLC, Puyallup, Washington, United States

Northwest Medical Specialties, PLLC, Tacoma, Washington, United States

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin, United States

University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin, United States

Asociación de Beneficencia Hospital Sirio Libanés, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina

Centro de Investigación Pergamino, Pergamino, Buenos Aires, Argentina

Sanatorio Británico, Rosario, Santa Fe Province, Argentina

Instituto de Oncología de Rosario, Rosario, Santa Fe Province, Argentina

Centro Oncologico Korben, Buenos Aires, Argentina

Orange Health Service, Orange, New South Wales, Australia

Sydney Adventist Hospital, Wahroonga, New South Wales, Australia

Icon Cancer Centre Chermside, Chermside, Queensland, Australia

Mater Misericordiae Limited Mater Cancer Care Centre, South Brisbane, Queensland, Australia

ICON Cancer Centre - Kurralta Park, Kurralta Park, South Australia, Australia

Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia

ZAS Augustinus, Wilrijk, Antwerpen, Belgium

Institut Jules Bordet, Anderlecht, Bruxelles-capitale, Région de, Belgium

Jessa Ziekenhuis, Hasselt, Limburg, Belgium

AZ Maria Middelares, Ghent, Oost-vlaanderen, Belgium

AZ Sint-Lucas, Ghent, Oost-vlaanderen, Belgium

UZ Leuven, Leuven, Vlaams-brabant, Belgium

AZ Groeninge Campus Kennedylaan, Kortrijk, West-vlaanderen, Belgium

AZORG Campus Aalst-Moorselbaan, Aalst, Belgium

Crio - Centro Regional Integrado de Oncologia, Fortaleza, Ceará, Brazil

Hospital Erasto Gaertner, Curitiba, Paraná, Brazil

ONCOSITE - Centro de Pesquisa Clinica em Oncologia, Ijuí, Rio Grande do Sul, Brazil

Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa, Porto Alegre, Rio Grande do Sul, Brazil

CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia, Santo André, São Paulo, Brazil

Hospital Alemao Oswaldo Cruz, São Paulo, São Paulo, Brazil

Centro de Estudos e Pesquisas Oncologia de Sorocaba (CEPOS), Sorocaba, São Paulo, Brazil

Instituto do Cancer Arnaldo Vieira de Carvalho, São Paulo, Brazil

IBCC - Núcleo de Pesquisa e Ensino, São Paulo, Brazil

MBAL Uni Hospital, Panagyurishte, Pazardzhik, Bulgaria

Medical Center Futuremeds, Plovdiv, Bulgaria

Complex Oncology Center - Plovdiv EOOD, Plovdiv, Bulgaria

Prostate Cancer Centre, Calgary, Alberta, Canada

Centre of Applied Urology Research/Nova Scotia Health Authority, Halifax, Nova Scotia, Canada

St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada

Lakeridge Health, Oshawa, Ontario, Canada

Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre, Greenfield Park, Quebec, Canada

Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada

Jewish General Hospital, Montreal, Quebec, Canada

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus, Québec, Quebec, Canada

Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer, Sherbrooke, Quebec, Canada

Diex Recherche Trois-Rivieres, Trois-Rivières, Quebec, Canada

Wannan Medical College Yijishan Hospital, Wuhu, Anhui, China

Peking University First Hospital, Beijing, Beijing Municipality, China

Beijing Friendship Hospital, Capital Medical University, Beijing, Beijing Municipality, China

The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing Municipality, China

Chongqing University Cancer Hospital, Chongqing, Chongqing Municipality, China

Lanzhou university second hospital, Lanzhou, Gansu, China

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei, China

Hunan Cancer Hospital, Changsha, Hunan, China

First Huai'an Hospital Affiliated to Nanjing Medical University, Huai'an, Jiangsu, China

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China

Nantong Tumor Hospital, Nantong, Jiangsu, China

The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

The First Hospital of China Medical University, Shenyang, Liaoning, China

The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China

Qilu Hospital of Shandong University, Jinan, Shandong, China

Fudan University Shanghai Cancer Center, Shanghai, Shanghai Municipality, China

Suining Central Hospital, Suining, Sichuan, China

Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

The first affiliated hospital of Ningbo university, Ningbo, Zhejiang, China

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

The Third Affiliated Hospital of Southern Medical University, Guangzhou, China

Fakultni Nemocnice u sv. Anny v Brne, Brno, South Moravian, Czechia

Masarykuv onkologicky ustav, Brno, Czechia

Fakultni nemocnice Hradec Kralove, Hradec Králové, Czechia

Fakultni nemocnice Olomouc, Olomouc, Czechia

Urocentrum Praha s.r.o., Prague, Czechia

Fakultni Thomayerova nemocnice, Prague, Czechia

Fakultni nemocnice v Motole, Prague, Czechia

Oulun yliopistollinen sairaala, Oulu, North Ostrobothnia, Finland

Kuopion Yliopistollinen Sairaala, Kuopio, Northern Savonia, Finland

Tampereen yliopistollinen sairaala, Tampere, Pirkanmaa, Finland

Vaasan Keskussairaala, Vaasa, Pohjanmaa, Finland

Turku University Hospital, Turku, Southwest Finland, Finland

Docrates Syöpäsairaala, Helsinki, Uusimaa, Finland

Helsinki university hospital, Helsinki, Finland

Centre Antoine-Lacassagne, Nice, Alpes-maritimes, France

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux, Aquitaine, France

Centre Leon Berard, Lyon Cedex08, Auvergne-Rhône-Alpes, France

Groupe Vivalto Santé - Clinique Pasteur-Lanroze, Brest, Brittany Region, France

CHU Besançon, Besançon, Doubs, France

Institut Godinot, Reims, Marne, France

Institut Jean Godinot, Reims, Marne, France

Centre Hospitalier de la Côte Basque, Bayonne, Pyrénées-atlantiques, France

Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône, France

Gustave Roussy, Villejuif, Val-de-marne, France

Institut de Cancérologie de l'Ouest, Angers, France

Henri Mondor Hospital, Créteil, Île-de-France Region, France

Heidelberg University Hospital, Heidelberg, Baden-Wurttemberg, Germany

Studienpraxis Urologie, Nürtingen, Baden-Wurttemberg, Germany

Universitaetsklinikum Ulm, Ulm, Baden-Wurttemberg, Germany

Universitaetsmedizin Goettingen, Göttingen, Lower Saxony, Germany

Urologie Neandertal - Praxis Mettmann, Mettmann, North Rhine-Westphalia, Germany

Universitätsklinikum Münster - Albert Schweitzer Campus, Münster, North Rhine-Westphalia, Germany

Universitätsklinikum Schleswig Holstein, Lübeck, Schleswig-Holstein, Germany

Charité Universitaetsmedizin Berlin, Berlin, Germany

Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany

Alexandra General Hospital of Athens, Athens, Attikí, Greece

General Hospital of Athens "G. Gennimatas", Athens, Greece

Metropolitan Hospital, Athens, Greece

Athens Medical Center S.A -European Interbalkan Medical Center, Thessaloniki, Greece

Rabin Medical Center, Petah Tikva, Central District, Israel

Sheba Medical Center, Ramat Gan, Central District, Israel

Yitzhak Shamir Medical Center, Ẕerifin, Central District, Israel

Shaare Zedek Medical Center, Jerusalem, Jerusalem, Israel

Hadassah Medical Center, Jerusalem, Jerusalem, Israel

Rambam Health Care Campus, Haifa, Northern District, Israel

Sourasky Medical Center, Tel Aviv, TELL ABĪB, Israel

IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Emilia-Romagna, Italy

Ospedale Santa Maria delle Croci, Ravenna, Emilia-Romagna, Italy

IRCCS Istituto Clinico Humanitas, Rozzano, Milano, Italy

Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano, Piedmont, Italy

Istituto Nazionale Tumori Regina Elena, Rome, ROMA, Italy

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Italy

Ospedale San Raffaele, Milan, Italy

Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Italy

Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy

ASUIT Trento - Santa Chiara Hospital, Trento, Italy

Centro Ricerche Cliniche di Verona, Verona, Italy

Chiba cancer center, Chiba, Chiba, Japan

National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan

National Hospital Organization Hokkaido Cancer Center, Sapporo, Hokkaido, Japan

Hokkaido University Hospital, Sapporo, Hokkaido, Japan

Kobe University Hospital, Kobe, Hyōgo, Japan

Kanazawa University Hospital, Kanazawa, Ishikawa-ken, Japan

Yokohama City University Medical Center, Yokohama, Kanagawa, Japan

Yokosuka Kyosai Hospital, Yokosuka, Kanagawa, Japan

The University of Osaka Hospital, Suita, Osaka, Japan

Keio university hospital, Shinjuku-ku, Tokyo, Japan

National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan

National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan

Osaka International Cancer Institute, Osaka, Japan

Yamagata University Hospital, Yamagata, Japan

Canisius-Wilhelmina Ziekenhuis, Nijmegen, Gelderland, Netherlands

Tergooiziekenhuizen, locatie Hilversum, Hilversum, North Holland, Netherlands

Reinier de Graaf Ziekenhuis, locatie Delft, Delft, South Holland, Netherlands

Tauranga Hospital, Tauranga, Bay of Plenty, New Zealand

Christchurch Hospital, Christchurch, Canterbury, New Zealand

Waikato Hospital, Hamilton, Waikato Region, New Zealand

Auckland City Hospital, Auckland, New Zealand

Palmerston North Hospital, Palmerston North, New Zealand

Clinical Research Center Spółka z ograniczoną odpowiedzialnością MEDIC-R Sp.k, Poznan, Greater Poland Voivodeship, Poland

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie, Krakow, Lesser Poland Voivodeship, Poland

POLIMED CLINIC Sp. z o.o., Wroclaw, Lower Silesian Voivodeship, Poland

Zachodniopomorskie Centrum Onkologii, Szczecin, West Pomeranian Voivodeship, Poland

Zachodniopomorskie Centrum Onkologii, Szczecin, Zachodniopomorskie Voivodeship, Poland

Szpitale Pomorskie Sp. z o.o., Gdynia, Poland

Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie, Koszalin, Poland

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o .o., Krakow, Poland

Clinical Best Solutions Sp. z o.o. S.K., Lublin, Poland

Centrum Medyczne MEDYK, Rzeszów, Poland

EMC Instytut Medyczny S.A., Wroclaw, Poland

Narodny onkologicky ustav, Bratislava, Slovakia

Vychodoslovensky onkologicky ustav, a.s., Košice, Slovakia

MILAB, s.r.o., Urologicka ambulancia, Prešov, Slovakia

Privatna urologicka ambulancia, s.r.o., Trenčín, Slovakia

Chonnam National University Hwasun Hospital, Hwasun-gun, Jeonranamdo, South Korea

National Cancer Center, Goyang-si, Kyǒnggi-do, South Korea

Seoul National University Bundang Hospital, Seongnam, Kyǒnggi-do, South Korea

Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [seoul], South Korea

Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [seoul], South Korea

Asan Medical Center, Seoul, Seoul-teukbyeolsi [seoul], South Korea

Samsung Medical Center, Seoul, Seoul-teukbyeolsi [seoul], South Korea

Ewha Womans University Mokdong Hospital, Seoul, Seoul-teukbyeolsi [seoul], South Korea

Kyungpook National University Chilgok Hospital, Deagu, Taegu-kwangyǒkshi, South Korea

Chungnam national university hospital, Junggu, Taejǒn-kwangyǒkshi, South Korea

Parc de Salut Mar - Hospital del Mar, Barcelona, Barcelona [barcelona], Spain

Althaia, Xarxa Assistencial Universitària de Manresa, Manresa, Barcelona, Spain

Hospital Clínic de Barcelona, Barcelona, Catalunya [cataluña], Spain

Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad de, Spain

Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad de, Spain

Hospital Universitario Virgen de la Victoria, Málaga, Málaga, Spain

CHUVI- Hospital Alvaro Cunqueiro, Vigo, Pontevedra [pontevedra], Spain

Fundación Instituto Valenciano de Oncología, Valencia, Valenciana, Comunitat, Spain

Hospital Clinico San Carlos, Madrid, Spain

Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain

Hospital General Universitario de Valencia, Valencia, Spain

Inselspital Bern, Bern, Canton of Bern, Switzerland

Kantonsspital Winterthur, Winterthur, Switzerland

UniversitätsSpital Zürich, Zurich, Switzerland

Chang Gung Medical Foundation-Linkou Branch, Guishan Dist., Taoyuan, Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, Taiwan

Taichung Veterans General Hospital, Taichung, Taiwan

National Cheng Kung University Hospital, Tainan, Taiwan

National Taiwan University Hospital, Taipei, Taiwan

Taipei Veterans General Hospital, Taipei, Taiwan

İ.A.Ü VM Medical Park Florya Hastanesi, Istanbul, İ̇stanbul, Turkey (Türkiye)

I.E.U. Medical Point Hastanesi, Izmir, İ̇zmir, Turkey (Türkiye)

Dokuz Eylul Universitesi Hastanesi, Izmir, İ̇zmir, Turkey (Türkiye)

Gulhane Egitim Arastirma Hastanesi, Ankara, Turkey (Türkiye)

Memorial Ankara Hastanesi, Ankara, Turkey (Türkiye)

Ankara University Health Practice and Research Hospitals, Ankara, Turkey (Türkiye)

Dicle Üniversitesi, Diyarbakır, Turkey (Türkiye)

Royal Blackburn Hospital, Blackburn, Blackburn WITH Darwen, United Kingdom

Velindre Cancer Centre, Cardiff, Cardiff [caerdydd Gb-crd], United Kingdom

Derriford Hospital, Plymouth, Devon, United Kingdom

Torbay Hospital, Torquay, Devon, United Kingdom

Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, Hammersmith and Fulham, United Kingdom

Royal Marsden Hospital (Chelsea), London, Kensington and Chelsea, United Kingdom

Maidstone Hospital, Maidstone, KENT, United Kingdom

Guy's & St Thomas' NHS Foundation Trust, London, London, CITY of, United Kingdom

Western General Hospital, Edinburgh, Midlothian, United Kingdom

The Christie NHS Foundation Trust, Manchester, United Kingdom