Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

Banner MD Anderson Cancer Center, Gilbert, Arizona, United States

Beverly Hills Cancer Center, Beverly Hills, California, United States

City of Hope National Medical Center, Duarte, California, United States

Cedars-Sinai Medical Center, Los Angeles, California, United States

Stanford Women's Cancer Center, Palo Alto, California, United States

University of California, Davis Comprehensive Cancer Center, Sacramento, California, United States

University of California San Diego Moores Cancer Center, San Diego, California, United States

University of California San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States

Kaiser Permanente Medical Center, Vallejo, California, United States

Rocky Mountain Cancer Centers, LLP, Longmont, Colorado, United States

Yale-New Haven Hospital-Yale Cancer Center, New Haven, Connecticut, United States

Medical Oncology Hematology Consultants, P.A., Newark, Delaware, United States

Georgetown University Medical Center, Washington D.C., District of Columbia, United States

AdventHealth, Altamonte Springs, Florida, United States

Florida Cancer Specialists-South, Fort Myers, Florida, United States

Cancer Care Centers of Brevard, Inc, Palm Bay, Florida, United States

Rush University Medical Center, Chicago, Illinois, United States

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, United States

Community Health Network, Inc, Indianapolis, Indiana, United States

University of Kansas Cancer Center, Westwood, Kansas, United States

Cancer Center of Kansas, Wichita, Kansas, United States

Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins, Baltimore, Maryland, United States

Tufts Medical Center, Boston, Massachusetts, United States

Dana Farber Cancer Institute, Boston, Massachusetts, United States

University of Michigan, Ann Arbor, Michigan, United States

Profound Research LLC, Royal Oak, Michigan, United States

Minnesota Oncology Hematology, P.A., Minneapolis, Minnesota, United States

University of Mississippi Medical Center, Jackson, Mississippi, United States

Washington University School of Medicine- Siteman Cancer Center, St Louis, Missouri, United States

Nebraska Cancer Specialists, Omaha, Nebraska, United States

Renown Health Medical Oncology, Reno, Nevada, United States

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, United States

Rutgers Cancer Institute, New Brunswick, New Jersey, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone Health, New York, New York, United States

Icahn School of Medicine at Mount Sinai, New York, New York, United States

Columbia University Irving Medical Center, New York, New York, United States

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon, United States

Avera Cancer Institute, Sioux Falls, South Dakota, United States

Tennessee Cancer Specialists, Knoxville, Tennessee, United States

Tennessee Oncology, PLLC, Nashville, Tennessee, United States

Texas Oncology Central/South, Austin, Texas, United States

Texas Oncology DFW, Dallas, Texas, United States

University of Texas Southwestern Medical Center, Dallas, Texas, United States

Houston Methodist Hospital Cancer Center, Houston, Texas, United States

The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States

Baylor Scott and White Medical Center, Temple, Texas, United States

Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States

Virginia Cancer Specialists, PC, Fairfax, Virginia, United States

Virginia Oncology Associates, Norfolk, Virginia, United States

University of Wisconsin Carbone Cancer Center- University Hospital, Madison, Wisconsin, United States

Centro Medico Dr. Doreski- Fundacion Respirar, Buenos Aires, Argentina

St. Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia

Sydney Adventist Hospital, Wahroonga, New South Wales, Australia

Barwon Health, Geelong, Victoria, Australia

Peter MacCallum Cancer Center, Melbourne, Victoria, Australia

Bayside Health (Alfred), Melbourne, Victoria, Australia

Sunshine Hospital, Saint Albans, Victoria, Australia

Ballarat Oncology & Haematology Clinical Research Fund, Wendouree, Victoria, Australia

Mater Hospital Sydney, North Sydney, Australia

Medical University of Graz, Graz, Austria

Ordensklinikum Linz GmbH, Linz, Austria

LKH Feldkirch, Interne E am LKH Rankweil, Rankweil, Austria

Institut Jules Bordet, Brussels, Belgium

Universitair Ziekenhuis Leuven, Leuven, Belgium

Centre Hospitalier de l'Ardenne, Libramont, Belgium

CHU-UCL Namur, Site Sainte-Elisabeth, Namur, Belgium

Vitaz, Sint-Niklaas, Belgium

CHR de Verviers site Tourelle, Verviers, Belgium

Centro de Oncologia do ABC- CEON+ Unidade Sao Caetano do Sul, São Caetano do Sul, São Paulo, Brazil

Oncolinicas do Brasil Serviços Médicos S.A (Oncocentro), Belo Horizonte, Brazil

Instituto do Câncer do Ceará, Fortaleza, Brazil

Oncoclinicas Natal- Centro de Pesquisa Oncology Natal, Natal, Brazil

Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil

Centro Gaúcho Integrado - Hospital Mae de Deus, Porto Alegre, Brazil

Associação Hospitalar Moinhos de Vento, Porto Alegre, Brazil

Uniao Brasileira de Educacao e Assistencia/ Hospital Sao Lucas da PUCRS, Porto Alegre, Brazil

Oncoclinicas Rio de Janeiro S.A., Rio de Janeiro, Brazil

Instituto de Educação Pesquisa e Gestão em Saúde, Rio de Janeiro, Brazil

Nucleo de Oncologia da Bahia S.A., Salvador, Brazil

MHAT "Dr. Tota Venkova", AD, Gabrovo, Bulgaria

William Osler Health System- Brampton Civic Hospital, Brampton, Ontario, Canada

The Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada

Sunnybrook Research Institute, Toronto, Ontario, Canada

Jewish General Hospital, Montreal, Quebec, Canada

Masarykuv onkologicky ustav, Brno, Czechia

University Hospital Hradec Kralove, Hradec Králové, Czechia

Aalborg University Hospital, Aalborg, Denmark

Zealand University Hospital, Næstved, Denmark

Sønderborg Sygehus, Sønderborg, Denmark

L'Institut de Cancérologie de l'Ouest (ICO) - Angers, Angers, France

CHU Besancon, Besançon, France

Centre François Baclesse, Caen, France

Centre Leon Berard, Lyon, France

Hôpital Privé Jean Mermoz, Lyon, France

Centre de Cancérologie du Grand Montpellier, Montpellier, France

Hopital du Leman, Thonon-les-Bains, France

Institut Claudius Regaud, Toulouse, France

Marienhospital Bottrop gGmbH, Bottrop, Germany

Studienzentrale für das MVZ Eggenfelden GbR, Eggenfelden, Germany

Praxis fuer Interdisziplinaere Onkologie und Haematologie, Freiburg im Breisgau, Germany

Universitaetsmedizin Mannheim, Mannheim, Germany

University General Hospital of Athens "Attikon", Athens, Greece

Iaso Hospital, Athens, Greece

General University Hospital of Crete, Heraklion, Greece

University Hospital of Larissa, Larissa, Greece

Interbalkan Hospital of Thessaloniki, Thessaloniki, Greece

Hong Kong United Oncology Centre, Hong Kong, Hong Kong

Queen Mary Hospital, Hong Kong, Hong Kong

Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili), Brescia, Italy

IRCCS Candiolo, Candiolo, Italy

AOU Ferrara, Arcispedale Sant'Anna, Cona, Italy

Azienda Ospedaliera Universitaria Careggi, Florence, Italy

Azienda USl Toscana Nord Ovest SC Oncologia Medica Ospedale Civile Livorno, Livorno, Italy

IRCCS Istituto Romagnolo per lo Studio Dei Tumori (IRST) "Dino Amadori", Meldola, Italy

IRCCS Ospedale San Raffaele, Milan, Italy

Hospital San Giuseppe, Milan, Italy

Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone, Palermo, Italy

Maastricht University Medical Center, Maastricht, Netherlands

Radboud UMC, Nijmegen, Netherlands

Zuyderland Medisch Centrum - Heerlen, Sittard, Netherlands

Haga Ziekenhuis, The Hague, Netherlands

Pratia MCM Krakow, Krakow, Poland

Mruk-Med Sp. z o.o, Rzeszów, Poland

Hospital da Luz, Lisbon, Portugal

Unidade Local de Saude de Loures Odivelas E.P.E. Hospital Beatriz Angelo, Loures, Portugal

Raffles Hospital, Singapore, Singapore

Curie Oncology (Farrer), Singapore, Singapore

CHA Bundang Medical Center, CHA University, Seongnam-si, South Korea

Seoul National University Hospital, Seoul, South Korea

Severance Hospital, Yonsei University Health System, Seoul, South Korea

Asan Medical Center, Seoul, South Korea

Gangnam Severance Hospital, Yonsei University Health System, Seoul, South Korea

Samsung Medical Center, Seoul, South Korea

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea

Korea University Guro Hospital, Seoul, South Korea

Seoul National University Bundang Hospital, Seoul, South Korea

Hospital Universitario de Badajoz, Badajoz, Spain

Hospital Universitari Vall d'Hebron, Barcelona, Spain

Hospital Clinic de Barcelona, Barcelona, Spain

Hospital San Pedro de Alcantara, Cáceres, Spain

Hospital Universitario Virgen de la Arrixaca, El Palmar, Spain

ICO Girona - Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain

Hospital Universitario Juan Ramon Jimenez, Huelva, Spain

Hospital Universitari Arnau de Vilanova, Lleida, Spain

Hospital Beata Maria Ana/IOB Madrid, Madrid, Spain

Clinica Universidad de Navarra, Madrid, Spain

Hospital Universitario 12 de Octubre, Madrid, Spain

Hospital General Universitario Morales Meseguer, Murcia, Spain

Hospital Universitario de Canarias, San Cristóbal de La Laguna, Spain

Instituto Valenciano de Oncologia (IVO), Valencia, Spain

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan

Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan

Taichung Veterans General Hospital, Taichung, Taiwan

National Taiwan University Hospital, Taipei, Taiwan

Taipei Veterans General Hospital, Taipei, Taiwan

Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan