A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

The Dignity Health Cancer Institute, Phoenix, Arizona, United States

Disney Family Cancer Center, Burbank, California, United States

Scripps Health, La Jolla, California, United States

Cancer and Blood Specialty Clinic, Los Alamitos, California, United States

Ellison Institute of Technology, Los Angeles, California, United States

Palo Alto Medical Foundation Research Center, Palo Alto, California, United States

Kaiser Permanente - San Marcos, San Marcos, California, United States

Palo Alto Medical Foundation Research Center, San Mateo, California, United States

Palo Alto Medical Foundation Research Center, Sunnyvale, California, United States

Cancer Specialists of North Florida - Jacksonville, Jacksonville, Florida, United States

Tallahassee Memorial HealthCare, Tallahassee, Florida, United States

Moffitt Cancer Center-McKinley Campus, Tampa, Florida, United States

Cleveland Clinic Florida, Weston, Florida, United States

Northwest Georgia Oncology Centers PC - Marietta, Marietta, Georgia, United States

Cancer Care Specialists of Central Illinois, O'Fallon, Illinois, United States

Springfield Clinic, Springfield, Illinois, United States

Carle Cancer Center, Urbana, Illinois, United States

Baptist Health Lexington, Lexington, Kentucky, United States

Baptist Health Hamburg, Lexington, Kentucky, United States

University of Kentucky - Markey Cancer Center, Lexington, Kentucky, United States

University of Louisville Hospital, Louisville, Kentucky, United States

Baptist Health Louisville, Louisville, Kentucky, United States

Velocity Clinical Research, Annapolis, Maryland, United States

University of Maryland, Baltimore, Maryland, United States

Henry Ford Health System, Detroit, Michigan, United States

Cancer & Hematology Centers of Western Michigan, Grand Rapids, Michigan, United States

University of Minnesota Medical Center, Minneapolis, Minnesota, United States

HCA Midwest Health, Kansas City, Missouri, United States

Nebraska Cancer Specialists, Grand Island, Nebraska, United States

Nebraska Cancer Specialists, Omaha, Nebraska, United States

Astera Cancer Care East Brunswick, East Brunswick, New Jersey, United States

Summit Medical Group, Florham Park, New Jersey, United States

The Blavatnik Family ? Chelsea Medical Center at Mount Sinai, New York, New York, United States

Mount Sinai West, New York, New York, United States

Icahn School of Medicine at Mount Sinai, New York, New York, United States

Memorial Sloan Kettering Cancer Center, New York, New York, United States

Duke Cancer Institute, Durham, North Carolina, United States

Fairview Hospital, Cleveland, Ohio, United States

Cleveland Clinic Foundation, Cleveland, Ohio, United States

Hillcrest Hospital, Mayfield Heights, Ohio, United States

Providence Portland Medical Center, Portland, Oregon, United States

Providence Oncology and Hematology Cancer Clinic - Westside;Investigation Drug Services Pharmacy, Portland, Oregon, United States

UPMC Hillman Cancer Center - Magee-Women?s Hospital, Pittsburgh, Pennsylvania, United States

Bon Secours - St. Francis Hospital, Greenville, South Carolina, United States

West Cancer Center, Germantown, Tennessee, United States

Vanderbilt University Medical Center, Nashville, Tennessee, United States

JPS Health Network, Fort Worth, Texas, United States

Community Clinical Trials, Kingwood, Texas, United States

Huntsman Cancer Hospital at the University of Utah, Salt Lake City, Utah, United States

Swedish Cancer Institute - Edmonds Campus, Edmonds, Washington, United States

Providence Regional Cancer Partnership, Everett, Washington, United States

Swedish Cancer Institute - Issaquah, Seattle, Washington, United States

Swedish Cancer Institute, Seattle, Washington, United States

Northwest Medical Specialties, Tacoma, Washington, United States

Centro Oncologico Korben, Caba, Argentina

Centro Médico Fleischer, Capital Federal, Argentina

Hospital Privado Centro Medico de Cordoba, Córdoba, Argentina

Instituto de Oncologia de Rosario, Rosario, Argentina

Centro Oncológico de Excelencia, San Juan, Argentina

Blacktown Hospital, Blacktown, New South Wales, Australia

Royal North Shore Hospital, St Leonards, New South Wales, Australia

Lyell McEwin Hospital, Elizabeth Vale, South Australia, Australia

Maroondah hospital;Oncology clinical trials, Ringwood, Victoria, Australia

Crio - Centro Regional Integrado de Oncologia, Fortaleza, Ceará, Brazil

Hospital Santa Rita de Cassia Vitoria, Vitória, Espírito Santo, Brazil

Obras Sociais Irma Dulce - Osid, Salvador, Estado de Bahia, Brazil

Hospital Araujo Jorge, Goiânia, Goiás, Brazil

Centro de Oncologia de Alfenas, Alfenas, Minas Gerais, Brazil

Hospital do Câncer de Londrina, Londrina, Paraná, Brazil

Hospital do Cancer de Pernambuco - HCP, Recife, Pernambuco, Brazil

Vencer Oncoclínica - Centro de Pesquisa do Piauí, Teresina, Piauí, Brazil

Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil

Hospital de Cancer de Barretos, Barretos, São Paulo, Brazil

Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo, São Paulo, Brazil

Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda, São Paulo, São Paulo, Brazil

Instituto Nacional de Cancer - INCa, Rio de Janeiro, Brazil

Arthur J.E. Child Comprehensive Cancer Center, Calgary, Alberta, Canada

Cross Cancer Institute, Edmonton, Alberta, Canada

CancerCare Manitoba, Winnipeg, Manitoba, Canada

The Moncton Hospital, Moncton, New Brunswick, Canada

The Ottawa Hospital Cancer Center, Ottawa, Ontario, Canada

Sault Area Hospital, Sault Ste. Marie, Ontario, Canada

Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

St. Joseph's Health Centre, Toronto, Ontario, Canada

Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada

Jewish General Hospital, Montreal, Quebec, Canada

Hôpital du Sacré-Coeur de Montreal, Montreal, Quebec, Canada

Unité de Recherche Clinique du CISSS de Laurentides, Saint-Jérôme, Quebec, Canada

Xiangyang Central Hospital, Xiangyang, Hubei, China

Peking Union Medical College Hospital, Beijing, China

Hunan Cancer Hospital, Changsha, China

West China Hospital of Sichuan University, Chengdu, China

Sichuan Provincial People's Hospital, Chengdu, China

Sun yat-sen University Cancer Center, Guangzhou, China

Sun Yat-Sen University Cancer Center - Huangpu Campus, Guangzhou, China

Zhejiang Cancer Hospital, Hangzhou, China

Harbin Medical University Cancer Hospital, Harbin, China

Jiangmen Central Hospital, Jiangmen, China

Shandong Cancer Hospital, Jinan, China

Jinhua municipal central hospital, Jinhua, China

Yunnan Cancer Hospital, Kunming, China

Guangxi Cancer Hospital of Guangxi Medical University, Nanning, China

Shantou Center Hospital, Shantou, China

Tianjin Cancer Hospital, Tianjin, China

Tianjin Cancer hospital Airport hospital, Tianjin, China

Xinjiang Medical University Cancer Hospital, Ürümqi, China

The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China

Shanxi Provincial People's Hospital, Xi'an, China

ICO Paul Papin, Angers, France

Centre Oscar Lambret, Lille, France

Centre Cancerologie Grand Montpellier, Montpellier, France

INSTITUT CURIE_SITE PARIS - Service d'Oncologie Médicale., Paris, France

Centre CARIO - HPCA, Plérin, France

Chu La Miletrie, Poitiers, France

Centre Eugene Marquis, Rennes, France

Centre Henri Becquerel, Rouen, France

HOPITAL RENE HUGUENIN- Institut Curie, Saint-Cloud, France

Ico Rene Gauducheau, Saint-Herblain, France

Institut Universitaire de Cancer de Toulouse Oncopole, Toulouse, France

Gustave Roussy, Villejuif, France

St. Elisabeth Krankenhaus Köln GmbH, Cologne, Germany

Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden, Dresden, Germany

Universitätsklinikum Essen, Essen, Germany

Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH, Essen, Germany

Kooperatives Mammazentrum Hamburg Krankenhaus Jerusalem, Hamburg, Germany

Medizinische Hochschule Zentrum Frauenheilkunde Abt.Gynäkologische Onkologie, Hanover, Germany

Nationales Centrum für Tumorerkrankungen (NCT), Heidelberg, Germany

InVO - Institut für Versorgungsforschung in der Onkologie GbR, Koblenz, Germany

Dres. Andreas Köhler und Roswitha Fuchs, Langen, Germany

Universitätsklinikum Münster, Münster, Germany

Klinikum Ernst von Bergmann, Potsdam, Germany

Caritas-Krankenhaus St. Josef, Regensburg, Germany

Caritas Klinik St. Theresia -Frauenklinik Brustzentrum, Saarbrücken, Germany

Universitätsklinik Tübingen, Tübingen, Germany

Universitätsklinikum Ulm Am Michelsberg, Ulm, Germany

Az. Osp. G. Panico, Tricase (LE), Apulia, Italy

A.O. S. Anna e San Sebastiano, Caserta, Campania, Italy

A.O. Universitaria Federico II Di Napoli, Naples, Campania, Italy

U.O.C. Oncologia Medica Senologica, Naples, Campania, Italy

Policlinico S.Orsola-Malpighi, Bologna, Emilia-Romagna, Italy

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola, Meldola, Emilia-Romagna, Italy

A.O. Universitaria Policlinico Di Modena, Modena, Emilia-Romagna, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Lazio, Italy

Asst Papa Giovanni XXIII, Bergamo, Lombardy, Italy

Ospedale San Raffaele, Milan, Lombardy, Italy

Irccs Istituto Nazionale Dei Tumori (Int), Milan, Lombardy, Italy

Istituto Clinico Humanitas, Rozzano, Lombardy, Italy

Humanitas Centro Catanese Di Oncologia, Misterbianco (CT), Sicily, Italy

Azienda Sanitaria dell'Alto Adige;U.O.C. Oncologia Medic, Bolzano, Trentino-Alto Adige, Italy

Ospedale Civile - Livorno, Livorno, Tuscany, Italy

University of Eastern Piedmont - Maggiore della Carità University Hospital, Novara, Umbria, Italy

A.O. Santa Maria Terni, Terni, Umbria, Italy

Chiba Cancer Center, Chiba, Japan

Fukushima Medical University Hospital, Fukushima, Japan

Hiroshima University Hospital, Hiroshima, Japan

Hokkaido University Hospital, Hokkaido, Japan

Kanagawa Cancer Center, Kanagawa, Japan

Tokai University Hospital, Kanagawa, Japan

Okayama University Hospital, Okayama, Japan

Saitama Medical University International Medical Center, Saitama, Japan

The Cancer Inst. Hosp. of JFCR, Tokyo, Japan

Instituto Nacional De Cancerologia, Distrito Federal, Mexico CITY (federal District), Mexico

Hospital General de Mexico, MexicoCiudad de México, Nuevo León, Mexico

Hospital Zambrano Hellion TecSalud, Monterrey, Nuevo León, Mexico

Centro de Investigacion y Tratamiento Integral del Cancer: CITI Cancer Oaxaca S.A de C.V., Ciudad de Huajuapan de León, Oaxaca, Mexico

Centro de Investigacion Clinica de Oaxaca, Oaxaca City, Oaxaca, Mexico

Centro Estatal de Cancerologia de Chihuahua, Chihuahua City, Mexico

Iem-Fucam, D.F., Mexico

Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico

Instytut "Centrum Zdrowia Matki Polki", ?ód?, Poland

Bialostockie Centrum Onkologii, Bialystok, Poland

Przychodnia Lekarska KOMED, Roman Karaszewski, Konin, Poland

Szpital Wojewódzki im. Miko?aja Kopernika, Koszalin, Poland

Szpital Miejski Specjalistyczny Narutowicza, Krakow, Poland

COZL Oddzial Onkologii Klinicznej z pododdzialem Chemioterapii Dziennej, Lublin, Poland

Wielkopolskie Centrum Onkologii im. Marii Sk?odowskiej-Curie, Późna, Poland

MRUKMED Lekarz Beata Madej-Mruk i Partner Spolka Partnerska Oddzial nr 1 w Rzeszowie, Rzeszów, Poland

Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad, Warsaw, Poland

Dolno?l?skie Centrum Onkologii, Wroc?aw, Poland

PanOncology Trials, San Juan, Puerto Rico

Linksfield Oncology Inc., Johannesburg, South Africa

Abraham Oncology, Richards Bay, South Africa

Wits Clinical Research, Soweto, South Africa

Kyungpook National University Chilgok Hospital, Daegu, South Korea

Soon Chun Hyang University Cheonan Hospital, Dongnam-gu, Cheonan-si, South Korea

National Cancer Center, Goyang-si, South Korea

Seoul National University Bundang Hospital, Seongnam-si, South Korea

Seoul National University Hospital, Seoul, South Korea

Severance Hospital, Yonsei University Health System, Seoul, South Korea

Asan Medical Center, Seoul, South Korea

Gangnam Severance Hospital, Seoul, South Korea

Samsung Medical Center, Seoul, South Korea

Hospital General Universitario de Elche, Elche, Alicante, Spain

ICO L'Hospitalet, L'Hospitalet de Llobregat, Barcelona, Spain

Hospital de Navarra, Pamplona/iruña, Navarre, Spain

Hospital de Basurto, Bilbao, Vizcaya, Spain

Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Barcelona, Spain

Hospital Universitario de la Princesa, Madrid, Spain

IOB Madrid Institute of Oncology Hospital Beata Maria Ana de Jesus;Unidad Central de Oncología Médica y de Investigación Oncológica, Madrid, Spain

Hospital General Univ. Gregorio Maranon, Madrid, Spain

Hospital Universitario Infanta Leonor, Madrid, Spain

Hospital Universitario Clínico San Carlos, Madrid, Spain

Hospital Universitario 12 De Octubre, Madrid, Spain

Hospital Clinico Universitario Virgen de la Victoria;Servicio de Oncologia, Málaga, Spain

Hospital Universitario Virgen del Rocio, Seville, Spain

Fundacion Instituto Valenciano de Oncologia (IVO), Valencia, Spain

Hospital Clinico Universitario de Valencia, Valencia, Spain

Kantonsspital Baden Zentrum für Onkologie und Hämatologie, Baden, Switzerland

Universitätsspital Basel, Basel, Switzerland

CHUV, Lausanne, Switzerland

Luzerner Kantonsspital, Lucerne, Switzerland

Chia-Yi Christian Hospital, Chiayi City, Taiwan

Taichung Veterans General Hospital, Taichung, Taiwan

National Cheng Kung Uni Hospital, Tainan, Taiwan

National Taiwan Uni Hospital, Taipei, Taiwan

Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan

Taipei Veterans General Hospital, Taipei, Taiwan

Abdurrahman Yurtarslan Onkoloji Training and Research Hospital, Ankara, Turkey (Türkiye)

Ankara City Hospital, Ankara, Turkey (Türkiye)

Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji, Bakirkoy / Istanbul, Turkey (Türkiye)

Ba?c?lar Medipol Mega Üniversite Hastanesi, Istanbul, Turkey (Türkiye)

Izmir Ataturk Training and Research Hospital, Izmir, Turkey (Türkiye)

Mersin City Education and Research Hospital, Mersin, Turkey (Türkiye)

Blackpool Victoria Hospital, Blackpool, United Kingdom

Colchester General Hospital, Colchester, Essex, United Kingdom

Western General Hospital, Edinburgh, United Kingdom

Princess Alexandra Hospital, Harlow, United Kingdom

St Bartholomew's Hospital, London, United Kingdom

Royal Free Hospital, London, United Kingdom

Mount Vernon & Watford Hospital Trust, Northwood, United Kingdom

Churchill Hospital - Oxford Cancer & Haematology Centre, Oxford, United Kingdom

Weston Park Hospital, Sheffield, United Kingdom