A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

Israel

RecruitingPHASE3

Simple summaryAI-assisted

This summary is produced by a language model and is experimental. It may be incomplete or inaccurate and is not a substitute for professional medical advice.

Conditions

Diffuse Large B-Cell Lymphoma

Locations

Banner MD Anderson Cancer Center ( Site 0165), Gilbert, Arizona, United States
Banner MD Anderson Cancer Center - University Medical Center Phoenix ( Site 0167), Phoenix, Arizona, United States
The University of Arizona Cancer Center - North Campus ( Site 0124), Tucson, Arizona, United States
Providence Medical Foundation-Oncology ( Site 0168), Fullerton, California, United States
Cancer Blood and Specialty Clinic ( Site 0109), Los Alamitos, California, United States
Cedars-Sinai Medical Center ( Site 0115), Los Angeles, California, United States
Pacific Hematology Oncology Associates ( Site 0131), San Francisco, California, United States
Lutheran Hospital - Cancer Centers of Colorado ( Site 0180), Golden, Colorado, United States
Clermont Oncology Center ( Site 0182), Clermont, Florida, United States
Bioresearch Partner ( Site 0157), Hialeah, Florida, United States
Orlando Health Cancer Institute ( Site 0169), Ocoee, Florida, United States
Mid Florida Hematology and Oncology Center ( Site 0172), Orange City, Florida, United States
Cancer Care Specialists of Illinois ( Site 0152), O'Fallon, Illinois, United States
Fort Wayne Medical Oncology and Hematology ( Site 0149), Fort Wayne, Indiana, United States
Cotton O'Neil Cancer Center ( Site 0108), Topeka, Kansas, United States
University of Kentucky ( Site 0106), Lexington, Kentucky, United States
Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0163), Louisville, Kentucky, United States
CHRISTUS St. Frances Cabrini Hospital Center for Cancer Care ( Site 0184), Alexandria, Louisiana, United States
Corewell Health ( Site 0130), Grand Rapids, Michigan, United States
The University of Mississippi Medical Center ( Site 0161), Jackson, Mississippi, United States
Circuit Clinical - SSM Health Cancer Care DePaul ( Site 0166), Bridgeton, Missouri, United States
Truman Medical Center ( Site 0122), Kansas City, Missouri, United States
Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana ( Site 0178), Billings, Montana, United States
OptumCare Cancer Care ( Site 0121), Las Vegas, Nevada, United States
Comprehensive Cancer Centers of Nevada ( Site 0113), Las Vegas, Nevada, United States
New York Oncology Hematology, P.C. ( Site 0129), Albany, New York, United States
Icahn School of Medicine at Mount Sinai ( Site 0164), New York, New York, United States
Prisma Health - Upstate ( Site 0158), Greenville, South Carolina, United States
Sanford Cancer Center ( Site 0143), Sioux Falls, South Dakota, United States
The University of Tennessee Medical Center ( Site 0142), Knoxville, Tennessee, United States
Center for Oncology and Blood Disorders ( Site 0153), Houston, Texas, United States
Houston Methodist Cancer Center ( Site 0154), Houston, Texas, United States
University of Virginia Cancer Center ( Site 0138), Charlottesville, Virginia, United States
Virginia Cancer Institute ( Site 0148), Richmond, Virginia, United States
Blue Ridge Cancer Care ( Site 0132), Roanoke, Virginia, United States
SSM Health Dean Medical Group ( Site 0140), Madison, Wisconsin, United States
Clinica Adventista Belgrano ( Site 0309), Caba., Buenos Aires, Argentina
Instituto de Investigaciones Clinicas Mar del Plata ( Site 0306), Mar del Plata, Buenos Aires, Argentina
Hospital Universitario Austral ( Site 0307), Pilar, Buenos Aires, Argentina
Hospital Aleman ( Site 0301), Buenos Aires, Buenos Aires F.D., Argentina
Fundacion Estudios Clinicos ( Site 0311), Rosario, Santa Fe Province, Argentina
C.I.C.E. 9 de Julio ( Site 0305), San Miguel de Tucumán, Tucumán Province, Argentina
Hospital Italiano de Buenos Aires ( Site 0304), CABA, Argentina
Clinica EL Castaño ( Site 0312), San Juan, Argentina
Townsville University Hospital ( Site 3006), Douglas, Queensland, Australia
Royal Adelaide Hospital ( Site 3001), Adelaide, South Australia, Australia
Grampians Health ( Site 3003), Ballarat, Victoria, Australia
Northern Hospital ( Site 3002), Melbourne, Victoria, Australia
Royal Perth Hospital-Haematology ( Site 3004), Perth, Western Australia, Australia
AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 1102), Mechelen, Antwerpen, Belgium
ASBL CHU Helora - Hôpital de Mons - Site Kennedy ( Site 1103), Mons, Hainaut, Belgium
CEONC ( Site 0412), Cascavel, Paraná, Brazil
Hospital Erasto Gaertner ( Site 0401), Curitiba, Paraná, Brazil
Liga Norte Riograndense Contra o Cancer ( Site 0407), Natal, Rio Grande do Norte, Brazil
CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina ( Site 0403), Florianópolis, Santa Catarina, Brazil
Hope ( Site 0413), Ribeirão Preto, São Paulo, Brazil
Clinica Advanze ( Site 0411), São Carlos, São Paulo, Brazil
F. F. R. M. São Jose do Rio Preto ( Site 0404), SJRP, São Paulo, Brazil
Hospital Paulistano ( Site 0406), São Paulo, Brazil
Hospital das Clinicas FMUSP ( Site 0402), São Paulo, Brazil
Queen Elizabeth II Health Sciences Centre ( Site 0207), Halifax, Nova Scotia, Canada
Lakeridge Health - The R.S. McLaughlin Durham Regional Cancer Centre (MDRCC) ( Site 0206), Oshawa, Ontario, Canada
Sunnybrook Research Institute ( Site 0204), Toronto, Ontario, Canada
Biocenter ( Site 0510), Concepción, Biobio, Chile
IC La Serena Research ( Site 0504), La Serena, Coquimbo Region, Chile
Oncocentro Valdivia ( Site 0506), Valdivia, Los Ríos Region, Chile
Centro de Estudios Clínicos SAGA ( Site 0508), Santiago, Region M. de Santiago, Chile
FALP ( Site 0501), Santiago, Region M. de Santiago, Chile
Clinica Inmunocel ( Site 0503), Santiago, Region M. de Santiago, Chile
Clínica RedSalud Vitacura ( Site 0512), Santiago, Region M. de Santiago, Chile
Bradfordhill ( Site 0502), Santiago, Region M. de Santiago, Chile
Centro de Investigaciones ( Site 0511), Viña del Mar, Valparaiso, Chile
Anhui Provincial Cancer Hospital ( Site 3124), Hefei, Anhui, China
Peking University Third Hospital ( Site 3102), Beijing, Beijing Municipality, China
Beijing Cancer Hospital ( Site 3101), Beijing, Beijing Municipality, China
Chongqing Cancer Hospital ( Site 3113), Chongqing, Chongqing Municipality, China
Fujian Provincial Cancer Hospital. ( Site 3119), Fuzhou, Fujian, China
The First Affiliated Hospital of Xiamen University ( Site 3120), Xiamen, Fujian, China
Sun Yat-sen University Cancer Center ( Site 3121), Guangzhou, Guangdong, China
Zhujiang Hospital of Southern Medical University ( Site 3122), Guangzhou, Guangdong, China
Affiliated Cancer Hospital of Guangxi Medical University ( Site 3123), Nanning, Guangxi, China
The Affiliated Hospital of Guizhou Medical University ( Site 3112), Guiyang, Guizhou, China
Hubei Cancer Hospital ( Site 3125), Wuhan, Hubei, China
Affiliated Hospital of Nantong University ( Site 3117), Nantong, Jiangsu, China
Jiangxi Cancer Hospital ( Site 3118), Nanchang, Jiangxi, China
The First Hospital Of Jilin University ( Site 3103), Changchun, Jilin, China
Shandong Cancer Hospital ( Site 3108), Jinan, Shandong, China
LinYi Cancer Hospital ( Site 3104), Linyi, Shandong, China
Fudan University Shanghai Cancer Center ( Site 3115), Shanghai, Shanghai Municipality, China
Shanxi Cancer Hospital ( Site 3106), Taiyuan, Shanxi, China
1st Affil Hosp of Med College of Xi'an Jiaotong University ( Site 3107), Xi’an, Shanxi, China
Sichuan Cancer Hospital. ( Site 3111), Chengdu, Sichuan, China
West China Hospital, Sichuan University ( Site 3110), Chengdu, Sichuan, China
Institute of Hematology and Blood Diseases Hosp CAMS&PUMC ( Site 3105), Tianjin, Tianjin Municipality, China
Yunnan Province Cancer Hospital ( Site 3109), Kunming, Yunnan, China
The First Affiliated Hospital, Zhejiang Medical University ( Site 3116), Hangzhou, Zhejiang, China
Hospital Pablo Tobon Uribe ( Site 0604), Medellín, Antioquia, Colombia
Hospital Universitario San Ignacio ( Site 0607), Bogotá, Bogota D.C., Colombia
IMAT S.A.S ( Site 0603), Montería, Departamento de Córdoba, Colombia
Oncologos del Occidente ( Site 0601), Pereira, Risaralda Department, Colombia
Fundación Valle del Lili ( Site 0602), Cali, Valle del Cauca Department, Colombia
University College Hospital, Department of Haematology ( Site 1303), Aarhus, Central Jutland, Denmark
Regionshospitalet Gødstrup ( Site 1301), Herning, Central Jutland, Denmark
Aalborg University Hospital ( Site 1302), Aalborg, North Denmark, Denmark
Centre Antoine-Lacassagne ( Site 1514), Nice, Alpes-Maritimes, France
Hopital Saint Louis, Centre Hospitalier de La Rochelle ( Site 1511), La Rochelle, Charente-Maritime, France
CHU Dijon Bourgogne ( Site 1516), Dijon, Cote-d Or, France
CHU GRENOBLE ALPES ( Site 1518), La Tronche, Isere, France
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1512), Limoges, Limousin, France
Centre Hospitalier Régional Metz Thionville - Hôpital de Mercy ( Site 1515), Metz, Moselle, France
Centre Hospitalier de Dunkerque ( Site 1513), Dunkirk, Nord, France
Centre Hospitalier Universitaire Estaing ( Site 1508), Clermont-Ferrand, Puy-de-Dome, France
Centre Hospitalier de la Cote Basque ( Site 1509), Bayonne, Pyrenees-Atlantiques, France
Centre Henri Becquerel ( Site 1517), Rouen, Seine-Maritime, France
HIA Sainte Anne ( Site 1506), Toulon, Var, France
Centre Hospitalier d'Avignon ( Site 1505), Avignon, Vaucluse, France
CHD Vendee ( Site 1502), La Roche-sur-Yon, Vendee, France
Institut Curie - site Saint-Cloud ( Site 1501), Saint-Cloud, Île-de-France Region, France
Evangelismos General Hospital of Athens ( Site 1602), Athens, Attica, Greece
General Hospital of Athens "Laiko"-Hematology Department ( Site 1603), Athens, Attica, Greece
Attikon University General Hospital of Athens ( Site 1604), Athens, Attica, Greece
University General Hospital of Alexandroupoli ( Site 1601), Alexandroupoli, Evros, Greece
MEDI-K ( Site 0701), Guatemala City, Guatemala
CELAN,S.A ( Site 0702), Guatemala City, Guatemala
Cen Integral Onco Gastro y Hemato Onco Guatemala S.A. ( Site 0703), Guatemala City, Guatemala
Princess Margaret Hospital ( Site 3202), Hong Kong, Hong Kong
Queen Mary Hospital ( Site 3201), Hong Kong, Hong Kong
Semmelweis University-Belgyógyászati és Hematológiai Klinika ( Site 1703), Budapest, Hajdú-Bihar, Hungary
Debreceni Egyetem Klinikai Kozpont ( Site 1702), Debrecen, Hajdú-Bihar, Hungary
Szabolcs Szatmár Bereg Vármegyei Oktatókórház ( Site 1704), Nyíregyháza, Szabolcs-Szatmár-Bereg, Hungary
Tolna Vármegyei Balassa János Kórház ( Site 1710), Szekszárd, Tolna County, Hungary
Carmel Hospital ( Site 1903), Haifa, Israel
Hadassah Medical Center ( Site 1901), Jerusalem, Israel
Sourasky Medical Center ( Site 1904), Tel Aviv, Israel
Poria Medical Center ( Site 1902), Tiberias, Israel
Fondazione IRCCS San Gerardo dei Tintori ( Site 2008), Monza, Lombardy, Italy
IRCCS Crob ( Site 2002), Rionero in Vulture, Potenza, Italy
Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia ( Site 2010), Candiolo, Torino, Italy
AOU delle Marche Ospedali Riuniti di Ancona ( Site 2011), Ancona, Italy
Azienda Ospedaliera Spedali Civili di Brescia-Hemathology ( Site 2001), Brescia, Italy
IRCCS Ospedale San Raffaele ( Site 2012), Milan, Italy
IEO Istituto Europeo di Oncologia ( Site 2009), Milan, Italy
Azienda Ospedaliero Universitaria Maggiore della Carità ( Site 2004), Novara, Italy
Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO ( Site 2005), Palermo, Italy
Ospedale Santa Maria delle Croci ( Site 2006), Ravenna, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 2003), Roma, Italy
Nagoya University Hospital ( Site 3309), Nagoya, Aichi-ken, Japan
National Cancer Center Hospital East ( Site 3303), Kashiwa, Chiba, Japan
National Hospital Organization Shikoku Cancer Center ( Site 3321), Matsuyama, Ehime, Japan
Kobe City Medical Center General Hospital ( Site 3318), Kobe, Hyōgo, Japan
Kanazawa University Hospital ( Site 3308), Kanazawa, Ishikawa-ken, Japan
Tokai University Hospital ( Site 3302), Isehara, Kanagawa, Japan
Tohoku University Hospital ( Site 3301), Sendai, Miyagi, Japan
Kindai University Hospital ( Site 3310), Sakai, Osaka, Japan
Saitama Medical University Hospital ( Site 3305), Iruma-gun, Saitama, Japan
Juntendo University Hospital ( Site 3307), Bunkyo, Tokyo, Japan
Tokyo Metropolitan Komagome Hospital ( Site 3323), Bunkyo, Tokyo, Japan
University of Yamanashi Hospital ( Site 3320), Chūō, Yamanashi, Japan
Chiba Cancer Center ( Site 3314), Chiba, Japan
Kyushu University Hospital ( Site 3313), Fukuoka, Japan
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital ( Site 3322), Hiroshima, Japan
University Hospital,Kyoto Prefectural University of Medicine ( Site 3315), Kyoto, Japan
University of Miyazaki Hospital ( Site 3319), Miyazaki, Japan
Okayama University Hospital ( Site 3311), Okayama, Japan
Osaka Metropolitan University Hospital ( Site 3317), Osaka, Japan
Yamagata University Hospital ( Site 3312), Yamagata, Japan
Queen Elizabeth Hospital ( Site 3405), Kota Kinabalu, Sabah, Malaysia
Sarawak General Hospital ( Site 3402), Kuching, Sarawak, Malaysia
Hospital Miri ( Site 3403), Miri, Sarawak, Malaysia
Sunway Medical Centre ( Site 3406), Petaling Jaya, Selangor, Malaysia
Hospital Ampang ( Site 3404), Selangor Darul Ehsan, Selangor, Malaysia
CIMAB SA de CV ( Site 0807), Torreón, Coahuila, Mexico
Grupo Ollin Care ( Site 0806), Pachuca, Hidalgo, Mexico
Health Pharma Professional Research S.A. de C.V. ( Site 0801), Mexico City, Mexico City, Mexico
Centro de Infusion Superare ( Site 0804), Mexico City, Mexico City, Mexico
Centro de Investigacion Clinica Chapultepec ( Site 0803), Morelia, Michoacán, Mexico
Hospital Universitario ""Dr. Jose Eleuterio Gonzalez"" ( Site 0802), Monterrey, Nuevo León, Mexico
Centro de Investigacion Clinica de Oaxaca ( Site 0805), Oaxaca City, Mexico
Albert Schweitzer Ziekenhuis ( Site 2103), Dordrecht, South Holland, Netherlands
Meander Medisch Centrum ( Site 2101), Amersfoort, Utrecht, Netherlands
Clínicas AUNA Sede Chiclayo ( Site 0904), Chiclayo, Lambayeque, Peru
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 0901), Surquillo, Muni Metro de Lima, Peru
Clínica San Felipe ( Site 0906), Lima, Peru
Hospital Nacional Edgardo Rebagliati Martins ( Site 0903), Lima, Peru
Hospital Nacional Dos De Mayo ( Site 0905), Lima, Peru
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 2201), Warsaw, Masovian Voivodeship, Poland
Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku ( Site 2210), Słupsk, Pomeranian Voivodeship, Poland
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2208), Gliwice, Silesian Voivodeship, Poland
Pratia Onkologia Katowice ( Site 2204), Katowice, Silesian Voivodeship, Poland
Szpital Kliniczny Ministerstwa Spraw Wewnętrznych i Administracji z Warmińsko-Mazurskim Centrum Onko ( Site 2205), Olsztyn, Warmian-Masurian Voivodeship, Poland
Unidade Local de Saude de Braga - Hospital de Braga ( Site 2306), Braga, Portugal
Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 2308), Lisbon, Portugal
Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E. ( Site 2302), Porto, Portugal
BRCR Global - Mayaguez ( Site 1003), Mayagüez, Puerto Rico
Auxilio Mutuo Cancer Center ( Site 1001), San Juan, Puerto Rico
Spitalul Clinic Colțea ( Site 2401), Bucharest, Bucharest, Romania
Institutul Oncologic Cluj ( Site 2404), Cluj-Napoca, Cluj, Romania
Centrul de Diagnostic si Tratament Oncologic Brasov ( Site 2402), Brasov, Romania
Spital Judetean Sibiu ( Site 2405), Sibiu, Romania
National University Hospital ( Site 3702), Singapore, Central Singapore, Singapore
National Cancer Centre Singapore ( Site 3701), Singapore, Central Singapore, Singapore
LIFE GROENKLOOF-Mary Potter Cancer Centre ( Site 2506), Pretoria, Gauteng, South Africa
Netcare Pretoria East Hospital ( Site 2502), Pretoria, Gauteng, South Africa
Haemalife ( Site 2501), Cape Town, Western Cape, South Africa
Groote Schuur Hospital ( Site 2504), Cape Town, Western Cape, South Africa
National Cancer Center- Center for Hemotologic malignancy ( Site 3806), Goyang-si, Kyonggi-do, South Korea
Pusan National University Hospital ( Site 3804), Busan, Pusan-Kwangyokshi, South Korea
Chungnam National University Hospital ( Site 3801), Daejeon, Taejon-Kwangyokshi, South Korea
Severance Hospital, Yonsei University Health System ( Site 3802), Seoul, South Korea
Asan Medical Center ( Site 3803), Seoul, South Korea
Samsung Medical Center ( Site 3807), Seoul, South Korea
St.Mary's H., Youido ( Site 3805), Seoul, South Korea
Hospital Universitario Virgen Macarena ( Site 2608), Seville, Andalusia, Spain
ICO L Hospitalet ( Site 2601), L'Hospitalet de Llobregat, Barcelona, Spain
H. Insular de Gran Canaria ( Site 2606), Las Palmas de Gran Canaria, Las Palmas, Spain
Hospital General Universitario Dr. Balmis ( Site 2604), Alicante, Valenciana, Comunitat, Spain
Hospital del Mar ( Site 2610), Barcelona, Spain
Hospital General Universitario 12 de Octubre ( Site 2605), Madrid, Spain
Hospital Universitario La Paz ( Site 2611), Madrid, Spain
Hospital Virgen de la Victoria ( Site 2609), Málaga, Spain
Hospital Universitario Miguel Servet ( Site 2607), Zaragoza, Spain
Kantonspital Baden ( Site 2703), Baden, Canton of Aargau, Switzerland
Cantonal Hospital St.Gallen-Oncology & Hematology ( Site 2702), Sankt Gallen, Canton of St. Gallen, Switzerland
Ospedale Regionale Bellinzona e Valli ( Site 2701), Bellinzona, Canton Ticino, Switzerland
Ospedale Italiano Lugano (OIL) ( Site 2705), Lugano, Canton Ticino, Switzerland
Chang Gung Memorial Hospital - Linkou Branch ( Site 3903), Taoyuan, Taoyuan, Taiwan
Chang Gung Memorial Hospital at Kaohsiung ( Site 3905), Kaohsiung City, Taiwan
National Cheng Kung University Hospital ( Site 3902), Tainan, Taiwan
National Taiwan University Hospital ( Site 3901), Taipei, Taiwan
Mackay Memorial Hospital ( Site 3908), Taipei, Taiwan
Tri-Service General Hospital ( Site 3906), Taipei, Taiwan
Faculty of Medicine Siriraj Hospital ( Site 4001), Bangkoknoi, Bangkok, Thailand
Chulalongkorn University ( Site 4003), Pathumwan, Bangkok, Thailand
Maharaj Nakorn Chiang Mai Hospital ( Site 4002), Muang, Chiang Mai, Thailand
Ondokuz Mayıs Universitesi ( Site 2806), Korfez Mahallesi, Samsun, Turkey (Türkiye)
Namık Kemal University Medical Faculty ( Site 2807), Suleymanpasa, Tekirdas, Turkey (Türkiye)
Baskent Universitesi Adana Dr. Turgut Noyan UAM ( Site 2809), Adana, Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi ( Site 2803), Ankara, Turkey (Türkiye)
Hacettepe Universite Hastaneleri ( Site 2810), Ankara, Turkey (Türkiye)
Ankara University Faculty of Medicine ( Site 2801), Ankara, Turkey (Türkiye)
Antalya Egitim ve Arastirma Hastanesi ( Site 2805), Antalya, Turkey (Türkiye)
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi ( Site 2804), Istanbul, Turkey (Türkiye)
MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( Site 2904), Cherkasy, Cherkasy Oblast, Ukraine
Communal non-profit enterprise "Regional clinical hospital of Ivano-Frankivsk Regional Council" ( Site 2906), Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine
Khmelnytskyi Regional Hospital ( Site 2907), Khmelnytskiy, Khmelnytskyi Oblast, Ukraine
Institute of Blood Pathology and Transfusion Medicine AMS Ukraine ( Site 2903), Lviv, Lviv Oblast, Ukraine
SNPE National Cancer Institute ( Site 2902), Kyiv, Ukraine
Universal Clinic Oberig ( Site 2908), Kyiv, Ukraine
SI National Research Center of Radiation Medicine, Hematology, Oncology ( Site 2901), Kyiv, Ukraine
Public Non-Profit Enterprise Kyiv City Clinical Hospital #9 under the Executive Body of Kyiv City Co ( Site 2905), Kyiv, Ukraine

View source on ClinicalTrials.gov Contact study team (email)