Lovastatin and Pembrolizumab for the Treatment of Patients With Recurrent or Metastatic Head and Neck Cancer, LAPP Trial

Abroad (travel likely)RecruitingPHASE2

Conditions

Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Human Papillomavirus-Related Neck Squamous Cell Carcinoma of Unknown Primary · Metastatic Head and Neck Squamous Cell Carcinoma · Metastatic Hypopharyngeal Squamous Cell Carcinoma · Metastatic Laryngeal Squamous Cell Carcinoma · Metastatic Nasopharyngeal Squamous Cell Carcinoma · Metastatic Oral Cavity Squamous Cell Carcinoma · Metastatic Oropharyngeal Squamous Cell Carcinoma · Metastatic Paranasal Sinus Squamous Cell Carcinoma · Recurrent Head and Neck Squamous Cell Carcinoma · Recurrent Hypopharyngeal Squamous Cell Carcinoma · Recurrent Laryngeal Squamous Cell Carcinoma · Recurrent Nasopharyngeal Squamous Cell Carcinoma · Recurrent Oral Cavity Squamous Cell Carcinoma · Recurrent Oropharyngeal Squamous Cell Carcinoma · Recurrent Paranasal Sinus Squamous Cell Carcinoma · Stage IV Hypopharyngeal Carcinoma AJCC v8 · Stage IV Laryngeal Cancer AJCC v8 · Stage IV Lip and Oral Cavity Cancer AJCC v8 · Stage IV Nasopharyngeal Carcinoma AJCC v8 · Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8 · Stage IV Sinonasal Cancer AJCC v8

Simple summaryAI-assisted

This summary is produced by a language model and is experimental. It may be incomplete or inaccurate and is not a substitute for professional medical advice.

Locations

Emory University Hospital Midtown, Atlanta, Georgia, United States
Contact: Study coordinator (Ardith Deshay) · ardith.deshay.deshay@emory.edu · 404-686-1858
Contact: Principal Investigator (Nicole C. Schmitt, MD, FACS)
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States
Contact: Study coordinator (Ardith C. Deshay) · ardith.deshay.deshay@emory.edu · 404-686-1858
Contact: Principal Investigator (Nicole C. Schmitt, MD, FACS)

Study leads

Nicole C Schmitt, D, FACS
Principal Investigator
Emory University Hospital/Winship Cancer Institute

View source on ClinicalTrials.gov

Similar trials

Other trials that are currently recruiting and may be relevant based on condition, treatment, phase, or location

TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer

Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Metastatic Head and Neck Squamous Cell Carcinoma · Metastatic Hypopharyngeal Squamous Cell Carcinoma

Abroad (travel likely)RecruitingPHASE1

Atlanta, United States · Atlanta, United States

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Clinical Stage III Cutaneous Melanoma AJCC v8 · Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Clinical Stage IV Cutaneous Melanoma AJCC v8

Abroad (travel likely)RecruitingPHASE2

Phoenix, United States · Little Rock, United States

Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation

Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Cutaneous Squamous Cell Carcinoma of the Head and Neck · Head and Neck Carcinoma of Unknown Primary

Abroad (travel likely)Recruiting

Atlanta, United States

Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 · Recurrent Head and Neck Squamous Cell Carcinoma · Recurrent Hypopharyngeal Squamous Cell Carcinoma

Abroad (travel likely)RecruitingPHASE1

Pittsburgh, United States