Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)

UCSD Moores Cancer Center ( Site 0039), La Jolla, California, United States

UCLA Hematology/Oncology - Santa Monica ( Site 0044), Los Angeles, California, United States

University of Miami Hospital and Clinics, Sylvester Cancer Center-Cancer Research Services ( Site 0051), Miami, Florida, United States

University of Maryland-Greenebaum Comprehensive Cancer Center ( Site 0049), Baltimore, Maryland, United States

Rutgers Cancer Institute of New Jersey ( Site 0033), New Brunswick, New Jersey, United States

University Hospitals Cleveland Medical Center ( Site 0043), Cleveland, Ohio, United States

MEDICAL COLLEGE OF WISCONSIN-Cancer Center Clinical Trials Office ( Site 0020), Milwaukee, Wisconsin, United States

Macquarie University-MQ Health Clinical Trials Unit ( Site 0108), Macquarie University, New South Wales, Australia

Gallipoli Medical Research Ltd-GMRF CTU ( Site 0107), Greenslopes, Queensland, Australia

Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0110), Melbourne, Victoria, Australia

Centre Hospitalier de l'Université de Montréal ( Site 0200), Montreal, Quebec, Canada

Jewish General Hospital ( Site 0206), Montreal, Quebec, Canada

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0207), Québec, Quebec, Canada

CIDO SpA-Oncology ( Site 0302), Temuco, Biobio, Chile

Clinica Universidad Catolica del Maule-Oncology ( Site 0304), Talca, Maule Region, Chile

FALP ( Site 0301), Santiago, Region M. de Santiago, Chile

Pontificia Universidad Catolica de Chile ( Site 0303), Santiago, Region M. de Santiago, Chile

Bradfordhill ( Site 0300), Santiago, Region M. de Santiago, Chile

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0406), Bogotá, Bogota D.C., Colombia

Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 0402), Bogotá, Bogota D.C., Colombia

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0400), Valledupar, Cesar Department, Colombia

IMAT S.A.S ( Site 0404), Montería, Departamento de Córdoba, Colombia

Fundación Valle del Lili-Oncology CIC ( Site 0403), Cali, Valle del Cauca Department, Colombia

Herlev and Gentofte Hospital ( Site 0501), Copenhagen, Capital Region, Denmark

Aalborg Universitetshospital, Syd ( Site 0503), Aalborg, North Denmark, Denmark

Vaasan Keskussairaala ( Site 0603), Vaasa, Pohjanmaa, Finland

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 0604), Helsinki, Uusimaa, Finland

Docrates Syöpäsairaala ( Site 0602), Helsinki, Uusimaa, Finland

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 0703), Bordeaux, Aquitaine, France

Hopitaux Universitaires de Strasbourg ( Site 0700), Strasbourg, Bas-Rhin, France

Hôpital Européen Georges Pompidou-Service d'Oncologie Médicale ( Site 0702), Paris, France

Gustave Roussy ( Site 0701), Villejuif, Île-de-France Region, France

Universitaetsklinikum Heidelberg ( Site 0805), Heidelberg, Baden-Wurttemberg, Germany

Universitaetsklinikum Tuebingen-Urologie ( Site 0801), Tübingen, Baden-Wurttemberg, Germany

klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Site 0802), Munich, Bavaria, Germany

Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0800), Berlin, Germany

Universitaetsklinikum Hamburg-Eppendorf-Onkologisches Zentrum ( Site 0804), Hamburg, Germany

St. Vincent's University Hospital ( Site 0901), Dublin, Dublin, Ireland

Cork University Hospital ( Site 0902), Cork, Ireland

Tallaght University Hospital ( Site 0900), Dublin, Ireland

Rambam Health Care Campus-Oncology Division ( Site 1002), Haifa, Israel

Rabin Medical Center ( Site 1001), Petah Tikva, Israel

Sheba Medical Center ( Site 1000), Ramat Gan, Israel

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1102), Rome, Lazio, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1103), Milan, Lombardy, Italy

Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1101), Rozzano, Milano, Italy

Azienda Ospedaliera Universitaria Integrata Verona - Ospedal-Centro Ricerche Cliniche di Verona ( Site 1100), Verona, Italy

Toho University Sakura Medical Center ( Site 1201), Sakura, Chiba, Japan

Yokohama City University Medical Center ( Site 1203), Yokohama, Kanagawa, Japan

The Jikei University Hospital ( Site 1202), Mitato, Tokyo, Japan

Kyushu University Hospital ( Site 1204), Fukuoka, Japan

Auckland City Hospital ( Site 1333), Auckland, New Zealand

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1402), Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Oddzial Badan Wczesnych Faz ( Site 1400), Warsaw, Masovian Voivodeship, Poland

Uniwersyteckie Centrum Kliniczne ( Site 1405), Gdansk, Pomeranian Voivodeship, Poland

Asan Medical Center-Oncology ( Site 1500), Songpagu, Seoul, South Korea

Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1502), Seoul, South Korea

Samsung Medical Center-Division of Hematology/Oncology ( Site 1501), Seoul, South Korea

Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 1603), L'Hospitalet de Llobregat, Barcelona, Spain

Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 1600), Madrid, Madrid, Comunidad de, Spain

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1602), Barcelona, Spain

Hospital General Universitario Gregorio Marañón ( Site 1601), Madrid, Spain

Hospital Clinico San Carlos-Oncology Department ( Site 1604), Madrid, Spain

Chang Gung Memorial Hospital at Kaohsiung-Oncology and Hematology ( Site 1704), Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan

China Medical University Hospital ( Site 1703), Taichung, Taiwan

Taipei Veterans General Hospital ( Site 1701), Taipei, Taiwan

Chang Gung Medical Foundation-Linkou Branch-Medical Oncology ( Site 1702), Taoyuan, Taiwan

Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1802), Adana, Turkey (Türkiye)

Hacettepe Universite Hastaneleri-oncology hospital ( Site 1800), Ankara, Turkey (Türkiye)

Ankara Bilkent Şehir Hastanesi ( Site 1801), Ankara, Turkey (Türkiye)

Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1804), Istanbul, Turkey (Türkiye)

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1803), Istanbul, Turkey (Türkiye)

Addenbrooke's Hospital ( Site 1902), Cambridge, Cambridgeshire, United Kingdom

The Beatson West of Scotland Cancer Centre ( Site 1904), Glasgow, Glasgow City, United Kingdom

Royal Preston Hospital-Lancashire Clinical Research Facility ( Site 1900), Preston, Lancashire, United Kingdom

University College London Hospital ( Site 1905), London, London, City of, United Kingdom

Queen Elizabeth Hospital Birmingham ( Site 1903), Birmingham, United Kingdom