The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Conditions
Advanced Solid Tumor · Advanced Malignant Neoplasm · Metastatic Cancer · Metastatic Solid Tumor · Lung Cancer · Ovarian Cancer · Endometrial Cancer · Prostate Cancer · Colorectal Cancer · Breast Cancer · Other Cancer · Locally Advanced · Head and Neck Cancer · Gall Bladder Cancer · Small Cell Lung Cancer · Small Cell Lung Cancer ( SCLC ) · Small Cell Lung Carcinoma · NSCLC · NSCLC (Non-small Cell Lung Cancer) · SCLC · Non-Small Cell Lung Carcinoma · Triple Negative Breast Cancer · TNBC · HER2+ Breast Cancer · Non-Small Cell Lung Cancer · ER/PR Positive Breast Cancer · HER2- Breast Cancer · HER2-positive Breast Cancer · HER2-negative Breast Cancer · ER/PR(+), Her2(-) Breast Cancer
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Locations
University of California Irvine Chao Family Comprehensive Cancer Center, Irvine, California, United States
University of San Diego Moores Cancer Center, La Jolla, California, United States
Contact: Study coordinator (Shumei Kato, MD)UCLA Jonsson Comprehensive Cancer Center, Los Angeles, California, United States
Contact: Study coordinator (Gottfried Konecny, MD)USC Norris Comprehensive Cancer Center, Los Angeles, California, United States
Contact: Study coordinator (Anthony El-Khoueiry, MD)Rocky Mountain Cancer Center, Denver, Colorado, United States
Contact: Study coordinator (Allen Cohn, MD)Yale Cancer Center, New Haven, Connecticut, United States
Contact: Study coordinator (Patricia LoRusso, MD)Medical Oncology Hematology Consultants, Newark, Delaware, United States
Contact: Study coordinator (Jamal Misleh, MD)University of Miami - Sylvester Comprehensive Cancer Center, Miami, Florida, United States
Contact: Study coordinator (Gilberto de Lima Lopes Jr., MD)Advent Health, Orlando, Florida, United States
Contact: Study coordinator (Robert Holloway, MD)Florida Cancer Specialists South, Port Charlotte, Florida, United States
Contact: Study coordinator (Ivor Percent, MD)Massachusetts General Hospital, Boston, Massachusetts, United States
Contact: Study coordinator (Aparna Parikh, MD)Dana Farber Cancer Institute, Boston, Massachusetts, United States
Contact: Study coordinator (Geoffrey Shapiro, MD, PhD)Karmanos Cancer Institute, Detroit, Michigan, United States
Contact: Study coordinator (Dipesh Uprety, MD)University of Nebraska Medical Center Buffet Cancer Center, Omaha, Nebraska, United States
Contact: Study coordinator (Lindsey McAlarnen, MD, M.Sc.)Memorial Sloan Kettering, New York, New York, United States
Contact: Study coordinator (Alison Schram, MD)Duke University, Durham, North Carolina, United States
Contact: Study coordinator (Niharika Mettu, MD, PhD)The Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, United States
Contact: Study coordinator (Dale Shepard, MD)University of Oklahoma, Oklahoma City, Oklahoma, United States
Contact: Study coordinator (Debra Richardson, MD)Oregon Health & Science University (OHSU), Portland, Oregon, United States
Contact: Study coordinator (Shivaani Kummar, MD)Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania, United States
Contact: Study coordinator (Lainie Martin, MD)University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Contact: Study coordinator (Sarah Taylor, MD, PhD)WellSpan York Cancer Center, York, Pennsylvania, United States
Contact: Study coordinator (Ikechukwu Akunyili, MD)Medical University of South Carolina, Charleston, South Carolina, United States
Sarah Cannon Research Institute, Nashville, Tennessee, United States
Contact: Study coordinator (Melissa Johnson, MD)New Experimental Therapeutics - NEXT Oncology, Austin, Texas, United States
Contact: Study coordinator (Anthony Tolcher, MD)Texas Oncology, Bedford, Texas, United States
Contact: Study coordinator (Terrence Wong, MD)UTSW - Moody Outpatient Center - Parkland Health, Dallas, Texas, United States
Contact: Study coordinator (David Miller, MD)UT Southwest Simmons Cancer Center, Dallas, Texas, United States
Contact: Study coordinator (David Miller, MD)The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Contact: Study coordinator (Ecaterina Dumbrava, MD)New Experimental Therapeutics of San Antonio - NEXT Oncology, San Antonio, Texas, United States
Contact: Study coordinator (Anthony Tolcher, MD)Virginia Cancer Specialists, Fairfax, Virginia, United States
Contact: Study coordinator (Alexander Spira, MD)University of Washington, Fred Hutchinson Cancer Center, Seattle, Washington, United States
Contact: Study coordinator (Andrew Coveler, MD)University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States
Contact: Study coordinator (Nataliya Uboha, MD, PhD)Chris O'Brien Lifehouse Hospital, Camperdown, New South Wales, Australia
Contact: Study coordinator (Peter Grimison, MD)Mater Cancer Care Centre, South Brisbane, Queensland, Australia
Contact: Study coordinator (Catherine Shannon, MD)Flinders Medical Center, Bedford Park, South Australia, Australia
Contact: Study coordinator (Shwagi Sukumaran, MD)Monash Medical Centre, Clayton, Victoria, Australia
Contact: Study coordinator (Sophia Frentzas, MD)Linear Clinical Research, Nedlands, Western Australia, Australia
Contact: Study coordinator (Michael Millward, MD)ICANS - Institut de cancérologie Strasbourg Europe, Strasbourg, Bas-Rhin, France
Contact: Study coordinator (Lauriane Eberst, MD)Institut Bergonie, Bordeaux, Gironde, France
Contact: Study coordinator (Veronique Debien, MD)Institut Claudius Regaud, Toulouse, Haute-Garonne, France
Contact: Study coordinator (Carlos-Alberto Gomez-Roca, MD)EDOG Institut de Cancerologie de l'Ouest, Saint-Herblain, Loire-Atlantique, France
Contact: Study coordinator (Jean-Sebastien Frenel, MD)Centre Jean Perrin, Clermont-Ferrand, Puy-de-Dôme, France
Contact: Study coordinator (Xavier Durando, MD)Institut Gustave Roussy, Villejuif, Val-de-Marne, France
Contact: Study coordinator (Yohann Loriot, MD)Centre Léon Bérard Centre Régional de Lutte Contre Le Cancer, Lyon, France
Contact: Study coordinator (Isabelle Ray-Coquard, MD)CHU de Nîmes, Nîmes, France
Contact: Study coordinator (Frédéric Fiteni, MD, PhD)Institute Cancer De Lorraine, Vandœuvre-lès-Nancy, France
Contact: Study coordinator (Aurélien Lambert, MD)Nationale Centrum für Tumorerkrankungen (NCT) Heidelberg, Heidelberg, Baden-Wurttemberg, Germany
Contact: Study coordinator (Martin Haag, MD)Universitätsklinikum Augsburg, Augsburg, Bavaria, Germany
Contact: Study coordinator (Rainer Claus, MD)Asklepios Klinik Altona, Hamburg, Free and Hanseatic City of Hamburg, Germany
Contact: Study coordinator (Dirk Arnold, MD)Universitätsklinikum Frankfurt, Frankfurt am Main, Hesse, Germany
Universitätsklinikum Essen, Essen, North Rhine-Westphalia, Germany
Contact: Study coordinator (Marcel Wiesweg, MD)Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Lazio, Italy
Contact: Study coordinator (Anna Fagotti, MD)Istituti Fisioterapici Ospitalieri - Istituto Nazionale Tumori Regina Elena, Rome, Lazio, Italy
Contact: Study coordinator (Lorenza Landi, MD)ASST Grande Ospedale Metropolitano Niguarda, Milan, Lombardy, Italy
Contact: Study coordinator (Salvatore Siena, MD)Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Lombardy, Italy
Contact: Study coordinator (Massimo Di Nicola, MD)Istituto Europeo Di Oncologia, Milan, Lombardy, Italy
Contact: Study coordinator (Giuseppe Curigliano, MD)Istituto Clinico Humanitas, Rozzano, Lombardy, Italy
Contact: Study coordinator (Armando Santoro, MD)Fondazione del Piemonte per l'Oncologia (IRCCS), Candiolo, Torino, Italy
Contact: Study coordinator (Chiara Lazzari, MD)Humanitas San Pio X, Milan, Italy
Contact: Study coordinator (Domenica Lorusso, MD)IRCCS - lstituto Nazionale Tumori - Fondazione G. Pascale, Naples, Italy
Contact: Study coordinator (Anna Passarelli, MD)National University Hospital, Kent Ridge, Singapore
Contact: Study coordinator (David Shao Peng Tan, MD)National Cancer Center of Singapore, Singapore, Singapore
Contact: Study coordinator (Tira Tan, MD)Asan Medical Center, Seoul, South Korea
Contact: Study coordinator (Dae Ho Lee, MD)National Cancer Center, Seoul, South Korea
Contact: Study coordinator (Myong Cheol Lim, MD, PhD)Samsung Medical Center, Seoul, South Korea
Contact: Study coordinator (Chel Hun Choi, MD)Seoul University Hospital, Seoul, South Korea
Contact: Study coordinator (Seock-Ah Im, MD)Severance Hospital Yonsei University, Seoul, South Korea
Contact: Study coordinator (Jung-Yun Lee, MD)START MADRID_Hospital Universitario Fundacion Jimenez Diaz, Madrid, Madrid, Spain
Contact: Study coordinator (Victor Moreno Garcia, MD)START MADRID_Hospital Universitario HM Sanchinarro - CIOCC, Madrid, Madrid, Spain
Contact: Study coordinator (Irene Moreno, MD)Instituto de Investigacion Oncologica Vall d'Hebron (VHIO) - EPON, Barcelona, Spain
Contact: Study coordinator (Lorena Farinas, MD)NEXT Oncology-Hospital Quironsalud Barcelona, Barcelona, Spain
Contact: Study coordinator (Elena Garralda, MD)Hospital Universitario 12 de Octubre, Madrid, Spain
Contact: Study coordinator (Santiago Ponce Aix, MD)START Rioja, Rioja, Spain
Contact: Study coordinator (Maria de Miguel Luken, MD)Hospital Clinico Universitario de Valencia, Valencia, Spain
Contact: Study coordinator (José Alejandro Pérez Fidalgo, MD)Sarah Cannon Research Institute UK, London, Middlesex, United Kingdom
Contact: Study coordinator (Elisa Fontana, MD, PhD)Freeman Hospital, Newcastle upon Tyne, Tyne and Wear, United Kingdom
Contact: Study coordinator (Alastair Greystoke, MB ChB PhD)
Study leads
Marc Fellous, MD
Study Director
Sr. Vice President of Medical Affairs