Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)

IsraelCompletedPHASE3

Conditions

Carcinoma, Hepatocellular

Simple summaryAI-assisted

This summary is produced by a language model and is experimental. It may be incomplete or inaccurate and is not a substitute for professional medical advice.

Locations
  • Arizona Oncology Associates PC- HOPE ( Site 0770), Tucson, Arizona, United States

  • Scripps Clinic Torrey Pines ( Site 0714), La Jolla, California, United States

  • USC Norris Comprehensive Cancer Center ( Site 0717), Los Angeles, California, United States

  • UCLA Hematology/Oncology - Santa Monica ( Site 0720), Los Angeles, California, United States

  • UC Irvine Health ( Site 0718), Orange, California, United States

  • Yale Cancer Center ( Site 0724), New Haven, Connecticut, United States

  • Tampa General Hospital ( Site 0764), Tampa, Florida, United States

  • Mountain States Tumor Institute ( Site 0773), Boise, Idaho, United States

  • University of Iowa Hospital and Clinics ( Site 0729), Iowa City, Iowa, United States

  • University of Kansas Cancer Center ( Site 0731), Westwood, Kansas, United States

  • University of Louisville ( Site 0757), Louisville, Kentucky, United States

  • Tulane Medical Center ( Site 0787), New Orleans, Louisiana, United States

  • University Medical Center New Orleans ( Site 0733), New Orleans, Louisiana, United States

  • Henry Ford Hospital-GI/Hepatology Research ( Site 0735), Detroit, Michigan, United States

  • Saint Louis University ( Site 0769), St Louis, Missouri, United States

  • University of New Mexico Comprehensive Cancer Center ( Site 0805), Albuquerque, New Mexico, United States

  • Monter Cancer Center ( Site 0780), Lake Success, New York, United States

  • Icahn School of Medicine at Mount Sinai ( Site 0744), New York, New York, United States

  • Wake Forest Baptist Health ( Site 0741), Winston-Salem, North Carolina, United States

  • University of Cincinnati Medical Center ( Site 0791), Cincinnati, Ohio, United States

  • The Ohio State University Wexner Medical Center ( Site 0759), Columbus, Ohio, United States

  • ProMedica Flower Hospital ( Site 0796), Sylvania, Ohio, United States

  • Stephenson Cancer Center ( Site 0745), Oklahoma City, Oklahoma, United States

  • OHSU Center for Health & Healing ( Site 0746), Portland, Oregon, United States

  • Penn State Hershey Medical Center ( Site 0766), Hershey, Pennsylvania, United States

  • Houston Methodist Research Institute ( Site 0784), Houston, Texas, United States

  • Edwards Comprehensive Cancer Center ( Site 0786), Huntington, West Virginia, United States

  • St George Hospital ( Site 0005), Kogarah, New South Wales, Australia

  • Westmead Hospital-Gastroenterology & Hepatology ( Site 0009), Westmead, New South Wales, Australia

  • Princess Alexandra Hospital ( Site 0006), Brisbane, Queensland, Australia

  • Austin Health ( Site 0008), Heidelberg, Victoria, Australia

  • Alfred Health ( Site 0004), Melbourne, Victoria, Australia

  • Royal Perth Hospital ( Site 0002), Perth, Western Australia, Australia

  • Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 0057), Natal, Rio Grande do Norte, Brazil

  • Hospital Nossa Senhora da Conceição-Centro Integrado de Pesquisa em Oncologia ( Site 0056), Porto Alegre, Rio Grande do Sul, Brazil

  • Clinica de Oncologia Reichow ( Site 0052), Blumenau, Santa Catarina, Brazil

  • Fundação Pio XII - Hospital de Câncer de Barretos-Unidade de Pesquisa Clínica ( Site 0058), Barretos, São Paulo, Brazil

  • Fundacao Dr Amaral Carvalho ( Site 0050), Jaú, São Paulo, Brazil

  • Hospital de Base de Sao Jose de Rio Preto ( Site 0043), São José do Rio Preto, São Paulo, Brazil

  • BP - A Beneficencia Portuguesa de São Paulo ( Site 0046), São Paulo, São Paulo, Brazil

  • A.C. Camargo Cancer Center ( Site 0054), São Paulo, Brazil

  • Centro Investigación del Cáncer James Lind ( Site 0064), Temuco, Araucania, Chile

  • Centro de Oncología de Precisión-Oncology ( Site 0068), Santiago, Region M. de Santiago, Chile

  • Centro de Cancer Nuestra Senora de la Esperanza ( Site 0065), Santiago, Region M. de Santiago, Chile

  • Bradfordhill ( Site 0066), Santiago, Region M. de Santiago, Chile

  • Anhui Provincial Hospital ( Site 0092), Heifei, Anhui, China

  • Beijing Cancer Hospital ( Site 0099), Beijing, Beijing Municipality, China

  • Beijing Cancer Hospital ( Site 0105), Beijing, Beijing Municipality, China

  • Peking Union Medical College Hospital ( Site 0087), Beijing, Beijing Municipality, China

  • Chinese People s Liberation Army Army Characteristic Medical Center ( Site 0117), Chongqing, Chongqing Municipality, China

  • Chongqing University Three Gorges Hospital ( Site 0859), Chongqing, Chongqing Municipality, China

  • Mengchao Hepatobiliary Hospital of Fujian Medical University ( Site 0121), Fuzhou, Fujian, China

  • Fujian Provincial Cancer Hospital ( Site 0085), Fuzhou, Fujian, China

  • The First Affiliated Hospital of Fujian Medical University ( Site 0089), Fuzhou, Fujian, China

  • Zhongshan Hospital Fudan University (Xiamen Branch) ( Site 0133), Xiamen, Fujian, China

  • Zhujiang Hospital of Southern Medical University ( Site 0115), Guangzhou, Guangdong, China

  • Guangdong Provincial People s Hospital ( Site 0100), Guangzhou, Guangdong, China

  • NANFANG HOSPITAL SOUTHERN MEDICAL UNIVERSITY ( Site 0088), Guangzhou, Guangdong, China

  • SUN YAT-SEN UNIVERSITY CANCER CENTRE ( Site 0128), Guangzhou, Guangdong, China

  • Jinan University - Zhuhai People's Hospital-Intervention Department ( Site 0856), Zhuhai, Guangdong, China

  • Guangxi Medical University Affiliated Tumor Hospital-Hepatological surgery ( Site 0862), Nanning, Guangxi, China

  • Hainan General Hospital ( Site 0112), Haikou, Hainan, China

  • Harbin Medical University Cancer Hospital ( Site 0090), Harbin, Heilongjiang, China

  • Henan Cancer Hospital ( Site 0114), Zhengzhou, Henan, China

  • Tongji Hospital Tongji Medical,Science & Technology ( Site 0126), Wuhan, Hubei, China

  • Hubei Cancer Hospital ( Site 0101), Wuhan, Hubei, China

  • Hunan Provincial People's Hospital ( Site 0113), Changsha, Hunan, China

  • Hunan Cancer Hospital ( Site 0096), Changsha, Hunan, China

  • The First Affiliated Hospital of Soochow University ( Site 0120), Suzhou, Jiangsu, China

  • Jiangxi Provincial Cancer Hospital-Cancer Hospital ( Site 0134), Nanchang, Jiangxi, China

  • Xi'an International Medical Center Hospital ( Site 0860), Xi'an, Shaanxi, China

  • The Third Affiliated Hospital of the PLA Navy Medical University ( Site 0123), Shanghai, Shanghai Municipality, China

  • Fudan University Shanghai Cancer Center ( Site 0106), Shanghai, Shanghai Municipality, China

  • Zhongshan Hospital Fudan University ( Site 0084), Shanghai, Shanghai Municipality, China

  • The First Affiliated Hospital of Xi an Jiaotong University ( Site 0108), Xi’an, Shanxi, China

  • West China Hospital of Sichuan University ( Site 0119), Chengdu, Sichuan, China

  • Suining Central Hospital ( Site 0857), Suining, Sichuan, China

  • Tianjin Medical University Cancer Institute & Hospital ( Site 0098), Tianjin, Tianjin Municipality, China

  • Tianjin Third Central Hospital ( Site 0861), Tianjin, Tianjin Municipality, China

  • The First Hospital of Kunming ( Site 0124), Kunming, Yunnan, China

  • 2nd Affil Hosp of Zhejiang University College of Medicine ( Site 0110), Hangzhou, Zhejiang, China

  • Sir Run Run Shaw Hospital ( Site 0094), Hangzhou, Zhejiang, China

  • Zhejiang Cancer Hospital ( Site 0103), Hangzhou, Zhejiang, China

  • Ningbo Medical Center LiHuili Hospital ( Site 0132), Ningbo, Zhejiang, China

  • Hospital Pablo Tobon Uribe ( Site 0145), Medellín, Antioquia, Colombia

  • Administradora Country S.A. ( Site 0137), Bogotá, Bogota D.C., Colombia

  • Fundacion Cardiovascular de Colombia ( Site 0136), Piedecuesta, Santander Department, Colombia

  • Fundación Valle del Lili ( Site 0140), Cali, Valle del Cauca Department, Colombia

  • Herlev Hospital ( Site 0170), Herlev, Capital Region, Denmark

  • Aarhus Universitets hospital ( Site 0175), Aarhus N, Central Jutland, Denmark

  • Odense Universitetshospital ( Site 0160), Odense, Region Syddanmark, Denmark

  • Hopital de la Croix-Rousse ( Site 0193), Lyon, Auvergne, France

  • Hopital de la Timone ( Site 0188), Marseille, Bouches-du-Rhone, France

  • CHU Bordeaux Haut-Leveque ( Site 0185), Pessac, Gironde, France

  • C.H.U. de Nancy. Hopital de Brabois Adultes ( Site 0180), Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France

  • A.P.H. Paris, Hopital Henri Mondor ( Site 0179), Créteil, Val-de-Marne, France

  • Hopital Paul Brousse ( Site 0182), Villejuif, Val-de-Marne, France

  • Universitaetsklinikum Freiburg ( Site 0199), Freiburg im Breisgau, Baden-Wurttemberg, Germany

  • Krankenhaus Nord-West GmbH ( Site 0208), Frankfurt am Main, Hesse, Germany

  • Medizinische Hochschule Hannover ( Site 0200), Hanover, Lower Saxony, Germany

  • Universitaetsklinikum Bonn ( Site 0203), Bonn, North Rhine-Westphalia, Germany

  • Universitaetsklinikum Leipzig ( Site 0202), Leipzig, Saxony, Germany

  • Universitaetsklinikum Halle ( Site 0213), Halle, Saxony-Anhalt, Germany

  • Universitaetsklinikum Schleswig-Holstein-Campus Lubeck ( Site 0215), Lübeck, Schleswig-Holstein, Germany

  • Charite - Universitaetsmedizin ( Site 0204), Berlin, Germany

  • Universitaetsklinikum Hamburg-Eppendorf ( Site 0207), Hamburg, Germany

  • Prince of Wales Hospital ( Site 0242), Shatin, Hong Kong

  • Somogy Megyei Kaposi Mór Oktató Kórház-Oncology center ( Site 0267), Kaposvár, Somogy County, Hungary

  • Zala Megyei Szent Rafael Korhaz ( Site 0265), Zalaegerszeg, Zala County, Hungary

  • Semmelweis University ( Site 0264), Budapest, Hungary

  • St Vincents University Hospital ( Site 0690), Dublin, Ireland

  • Emek Medical Center ( Site 0307), Afula, Israel

  • Rambam Health Care Campus-Oncology Division ( Site 0305), Haifa, Israel

  • Hadassah Ein Karem Jerusalem ( Site 0303), Jerusaelm, Israel

  • Rabin Medical Center ( Site 0304), Petah Tikva, Israel

  • Sourasky Medical Center ( Site 0306), Tel Aviv, Israel

  • Ospedale del Mare ( Site 0327), Naples, Campania, Italy

  • ASST Grande Ospedale Metropolitano Niguarda-Oncologia Falck ( Site 0331), Milan, Milano, Italy

  • Ospedale Mauriziano-SCDU ONCOLOGIA MEDICA ( Site 0333), Turin, Piedmont, Italy

  • AOU Policlinico G. Martino ( Site 0324), Messina, Sicily, Italy

  • Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 0334), Brescia, Italy

  • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico ( Site 0325), Milan, Italy

  • Az Osp di Rilievo Nazionale A. Cardarelli ( Site 0329), Naples, Italy

  • Azienda USL della Romagna-Dipartimento di Oncologia ed Ematologia ( Site 0332), Ravenna, Italy

  • Policlinico Universitario -Agostino Gemelli ( Site 0328), Roma, Italy

  • National Cancer Center Hospital East ( Site 0347), Kashiwa, Chiba, Japan

  • Ehime University Hospital ( Site 0368), Tōon, Ehime, Japan

  • Kurume University Hospital ( Site 0362), Kurume, Fukuoka, Japan

  • Sapporo Kosei General Hospital ( Site 0345), Sapporo, Hokkaido, Japan

  • Kanazawa University Hospital ( Site 0354), Kanazawa, Ishikawa-ken, Japan

  • Kagawa Prefectural Central Hospital ( Site 0364), Takamatsu, Kagawa-ken, Japan

  • Toranomon Hospital Kajigaya ( Site 0369), Kawasaki, Kanagawa, Japan

  • Yokohama City University Medical Center ( Site 0351), Yokohama, Kanagawa, Japan

  • Kanagawa Cancer Center ( Site 0352), Yokohama, Kanagawa, Japan

  • Nara Medical University Hospital ( Site 0359), Kashihara, Nara, Japan

  • Kindai University Hospital ( Site 0358), Sayama, Osaka, Japan

  • Saitama Medical University Hospital ( Site 0370), Iruma-gun, Saitama, Japan

  • Shizuoka Cancer Center ( Site 0365), Suntogun, Shizuoka, Japan

  • Jichi Medical University Hospital ( Site 0353), Shimotsuke, Tochigi, Japan

  • Chiba University Hospital ( Site 0346), Chiba, Japan

  • National Hospital Organization Kyushu Medical Center ( Site 0361), Fukuoka, Japan

  • Hiroshima University Hospital ( Site 0360), Hiroshima, Japan

  • Kumamoto University Hospital ( Site 0372), Kumamoto, Japan

  • University Hospital,Kyoto Prefectural University of Medicine ( Site 0367), Kyoto, Japan

  • Osaka International Cancer Institute ( Site 0357), Osaka, Japan

  • Japanese Red Cross Osaka Hospital ( Site 0356), Osaka, Japan

  • Saga-Ken Medical Centre Koseikan ( Site 0363), Saga, Japan

  • Toranomon Hospital ( Site 0349), Tokyo, Japan

  • Juntendo University Hospital ( Site 0371), Tokyo, Japan

  • The University of Tokyo Hospital ( Site 0348), Tokyo, Japan

  • Maastricht University Medical Centre ( Site 0440), Maastricht, Limburg, Netherlands

  • AMC ( Site 0438), Amsterdam, North Holland, Netherlands

  • Leids Universitair Medisch Centrum-Medical Oncology ( Site 0442), Leiden, South Holland, Netherlands

  • Erasmus University Medical Center ( Site 0439), Rotterdam, South Holland, Netherlands

  • Universitair Medisch Centrum Utrecht-Medical Oncology ( Site 0441), Utrecht, Netherlands

  • Auckland City Hospital ( Site 0459), Auckland, New Zealand

  • Oslo Universitetssykehus Ullevål ( Site 0500), Oslo, Norway

  • Centro Hospitalar e Universitario de Coimbra ( Site 0502), Coimbra, Portugal

  • Unidade Local de Saude de São José - Hospital de Santo Antonio dos Capuchos ( Site 0505), Lisbon, Portugal

  • Centro Hospitalar do Porto, E.P.E. - Hospital Geral de Sto. Antonio ( Site 0504), Porto, Portugal

  • Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 0503), Porto, Portugal

  • Centro Hospitalar de Sao Joao. EPE - Hospital de Sao Joao ( Site 0501), Porto, Portugal

  • Puerto Rico Medical Research Center LLC ( Site 0523), Hato Rey, Puerto Rico

  • Ad-Vance Medical Research LLC ( Site 0527), Ponce, Puerto Rico

  • VA Caribbean Healthcare System ( Site 0524), San Juan, Puerto Rico

  • FDI Clinical Research ( Site 0522), San Juan, Puerto Rico

  • Chonnam National University Hwasun Hospital ( Site 0572), Hwasun, Jeonranamdo, South Korea

  • Seoul National University Bundang Hospital ( Site 0570), Seongnam-si, Kyonggi-do, South Korea

  • Pusan National University Hospital ( Site 0568), Busan, Pusan-Kwangyokshi, South Korea

  • Kyungpook National University Hospital ( Site 0569), Daegu, Taegu-Kwangyokshi, South Korea

  • Seoul National University Hospital ( Site 0567), Seoul, South Korea

  • Severance Hospital Yonsei University Health System ( Site 0564), Seoul, South Korea

  • Asan Medical Center ( Site 0565), Seoul, South Korea

  • Samsung Medical Center ( Site 0566), Seoul, South Korea

  • The Catholic University of Korea St. Mary s Hospital ( Site 0571), Seoul, South Korea

  • Korea University Guro Hospital ( Site 0573), Seoul, South Korea

  • Hospital Universitario Puerta de Hierro ( Site 0596), Majadahonda, Madrid, Spain

  • Hospital General Universitario de Valencia ( Site 0595), Valencia, Valenciana, Comunitat, Spain

  • Hospital General Universitario Gregorio Maranon ( Site 0598), Madrid, Spain

  • Hospital Ramon y Cajal ( Site 0593), Madrid, Spain

  • Hospital Clinico San Carlos ( Site 0597), Madrid, Spain

  • Hospital Virgen del Rocio ( Site 0591), Seville, Spain

  • Chang Gung Medical Foundation. Kaohsiung Branch ( Site 0609), Kaohsiung City, Kaohsiung, Taiwan

  • Kaohsiung Medical University Hospital ( Site 0611), Kaohsiung City, Taiwan

  • China Medical University Hospital-Surgical Department ( Site 0610), Taichung, Taiwan

  • Taichung Veterans General Hospital ( Site 0613), Taichung, Taiwan

  • National Cheng Kung University Hospital ( Site 0608), Tainan, Taiwan

  • National Taiwan University Hospital ( Site 0606), Taipei, Taiwan

  • Taipei Veterans General Hospital-Division of Gastroenterology & Hepatology, Department of Medicine ( Site 0612), Taipei, Taiwan

  • Chang Gung Medical Foundation. Linkou ( Site 0607), Taoyuan, Taiwan

  • Chulalongkorn University ( Site 0627), Bangkok, Bangkok, Thailand

  • Ramathibodi Hospital, Mahidol University ( Site 0628), Bangkok, Bangkok, Thailand

  • Faculty of Medicine Siriraj Hospital ( Site 0629), Bangkok, Bangkok, Thailand

  • Hacettepe University Medical Faculty ( Site 0653), Ankara, Turkey (Türkiye)

  • Ankara City Hospital-Medical Oncology ( Site 0661), Ankara, Turkey (Türkiye)

  • Trakya University Medical Faculty Balkan Oncology Hospital ( Site 0648), Edirne, Turkey (Türkiye)

  • Bezmialem Vakf Üniversitesi-Oncology ( Site 0660), Istanbul, Turkey (Türkiye)

  • Ege University Medical Faculty Tulay Aktas Oncology Hospital ( Site 0654), Izmir, Turkey (Türkiye)

  • I.E.U. Medical Point Hastanesi ( Site 0649), Izmir, Turkey (Türkiye)

  • Konya Necmettin Erbakan University Medical Faculty ( Site 0652), Konya, Turkey (Türkiye)

  • Inonu Universitesi Medical Fakultesi ( Site 0650), Malatya, Turkey (Türkiye)

  • Communal non profit enterprise Regional Clinical Oncology Center ( Site 0669), Kharkiv, Kharkiv Oblast, Ukraine

  • Barts Health NHS Trust ( Site 0692), London, London, City of, United Kingdom

  • Royal Marsden NHS Foundation Trust ( Site 0694), London, London, City of, United Kingdom

  • Royal Marsden NHS Trust ( Site 0693), Sutton, London, City of, United Kingdom

Study leads
  • Medical Director

    Study Director

    Merck Sharp & Dohme LLC