Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)

IsraelCompletedPHASE3

Conditions

Carcinoma, Hepatocellular

Simple summaryAI-assisted

This summary is produced by a language model and is experimental. It may be incomplete or inaccurate and is not a substitute for professional medical advice.

Locations

Arizona Oncology Associates PC- HOPE ( Site 0770), Tucson, Arizona, United States
Scripps Clinic Torrey Pines ( Site 0714), La Jolla, California, United States
USC Norris Comprehensive Cancer Center ( Site 0717), Los Angeles, California, United States
UCLA Hematology/Oncology - Santa Monica ( Site 0720), Los Angeles, California, United States
UC Irvine Health ( Site 0718), Orange, California, United States
Yale Cancer Center ( Site 0724), New Haven, Connecticut, United States
Tampa General Hospital ( Site 0764), Tampa, Florida, United States
Mountain States Tumor Institute ( Site 0773), Boise, Idaho, United States
University of Iowa Hospital and Clinics ( Site 0729), Iowa City, Iowa, United States
University of Kansas Cancer Center ( Site 0731), Westwood, Kansas, United States
University of Louisville ( Site 0757), Louisville, Kentucky, United States
Tulane Medical Center ( Site 0787), New Orleans, Louisiana, United States
University Medical Center New Orleans ( Site 0733), New Orleans, Louisiana, United States
Henry Ford Hospital-GI/Hepatology Research ( Site 0735), Detroit, Michigan, United States
Saint Louis University ( Site 0769), St Louis, Missouri, United States
University of New Mexico Comprehensive Cancer Center ( Site 0805), Albuquerque, New Mexico, United States
Monter Cancer Center ( Site 0780), Lake Success, New York, United States
Icahn School of Medicine at Mount Sinai ( Site 0744), New York, New York, United States
Wake Forest Baptist Health ( Site 0741), Winston-Salem, North Carolina, United States
University of Cincinnati Medical Center ( Site 0791), Cincinnati, Ohio, United States
The Ohio State University Wexner Medical Center ( Site 0759), Columbus, Ohio, United States
ProMedica Flower Hospital ( Site 0796), Sylvania, Ohio, United States
Stephenson Cancer Center ( Site 0745), Oklahoma City, Oklahoma, United States
OHSU Center for Health & Healing ( Site 0746), Portland, Oregon, United States
Penn State Hershey Medical Center ( Site 0766), Hershey, Pennsylvania, United States
Houston Methodist Research Institute ( Site 0784), Houston, Texas, United States
Edwards Comprehensive Cancer Center ( Site 0786), Huntington, West Virginia, United States
St George Hospital ( Site 0005), Kogarah, New South Wales, Australia
Westmead Hospital-Gastroenterology & Hepatology ( Site 0009), Westmead, New South Wales, Australia
Princess Alexandra Hospital ( Site 0006), Brisbane, Queensland, Australia
Austin Health ( Site 0008), Heidelberg, Victoria, Australia
Alfred Health ( Site 0004), Melbourne, Victoria, Australia
Royal Perth Hospital ( Site 0002), Perth, Western Australia, Australia
Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 0057), Natal, Rio Grande do Norte, Brazil
Hospital Nossa Senhora da Conceição-Centro Integrado de Pesquisa em Oncologia ( Site 0056), Porto Alegre, Rio Grande do Sul, Brazil
Clinica de Oncologia Reichow ( Site 0052), Blumenau, Santa Catarina, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos-Unidade de Pesquisa Clínica ( Site 0058), Barretos, São Paulo, Brazil
Fundacao Dr Amaral Carvalho ( Site 0050), Jaú, São Paulo, Brazil
Hospital de Base de Sao Jose de Rio Preto ( Site 0043), São José do Rio Preto, São Paulo, Brazil
BP - A Beneficencia Portuguesa de São Paulo ( Site 0046), São Paulo, São Paulo, Brazil
A.C. Camargo Cancer Center ( Site 0054), São Paulo, Brazil
Centro Investigación del Cáncer James Lind ( Site 0064), Temuco, Araucania, Chile
Centro de Oncología de Precisión-Oncology ( Site 0068), Santiago, Region M. de Santiago, Chile
Centro de Cancer Nuestra Senora de la Esperanza ( Site 0065), Santiago, Region M. de Santiago, Chile
Bradfordhill ( Site 0066), Santiago, Region M. de Santiago, Chile
Anhui Provincial Hospital ( Site 0092), Heifei, Anhui, China
Beijing Cancer Hospital ( Site 0099), Beijing, Beijing Municipality, China
Beijing Cancer Hospital ( Site 0105), Beijing, Beijing Municipality, China
Peking Union Medical College Hospital ( Site 0087), Beijing, Beijing Municipality, China
Chinese People s Liberation Army Army Characteristic Medical Center ( Site 0117), Chongqing, Chongqing Municipality, China
Chongqing University Three Gorges Hospital ( Site 0859), Chongqing, Chongqing Municipality, China
Mengchao Hepatobiliary Hospital of Fujian Medical University ( Site 0121), Fuzhou, Fujian, China
Fujian Provincial Cancer Hospital ( Site 0085), Fuzhou, Fujian, China
The First Affiliated Hospital of Fujian Medical University ( Site 0089), Fuzhou, Fujian, China
Zhongshan Hospital Fudan University (Xiamen Branch) ( Site 0133), Xiamen, Fujian, China
Zhujiang Hospital of Southern Medical University ( Site 0115), Guangzhou, Guangdong, China
Guangdong Provincial People s Hospital ( Site 0100), Guangzhou, Guangdong, China
NANFANG HOSPITAL SOUTHERN MEDICAL UNIVERSITY ( Site 0088), Guangzhou, Guangdong, China
SUN YAT-SEN UNIVERSITY CANCER CENTRE ( Site 0128), Guangzhou, Guangdong, China
Jinan University - Zhuhai People's Hospital-Intervention Department ( Site 0856), Zhuhai, Guangdong, China
Guangxi Medical University Affiliated Tumor Hospital-Hepatological surgery ( Site 0862), Nanning, Guangxi, China
Hainan General Hospital ( Site 0112), Haikou, Hainan, China
Harbin Medical University Cancer Hospital ( Site 0090), Harbin, Heilongjiang, China
Henan Cancer Hospital ( Site 0114), Zhengzhou, Henan, China
Tongji Hospital Tongji Medical,Science & Technology ( Site 0126), Wuhan, Hubei, China
Hubei Cancer Hospital ( Site 0101), Wuhan, Hubei, China
Hunan Provincial People's Hospital ( Site 0113), Changsha, Hunan, China
Hunan Cancer Hospital ( Site 0096), Changsha, Hunan, China
The First Affiliated Hospital of Soochow University ( Site 0120), Suzhou, Jiangsu, China
Jiangxi Provincial Cancer Hospital-Cancer Hospital ( Site 0134), Nanchang, Jiangxi, China
Xi'an International Medical Center Hospital ( Site 0860), Xi'an, Shaanxi, China
The Third Affiliated Hospital of the PLA Navy Medical University ( Site 0123), Shanghai, Shanghai Municipality, China
Fudan University Shanghai Cancer Center ( Site 0106), Shanghai, Shanghai Municipality, China
Zhongshan Hospital Fudan University ( Site 0084), Shanghai, Shanghai Municipality, China
The First Affiliated Hospital of Xi an Jiaotong University ( Site 0108), Xi’an, Shanxi, China
West China Hospital of Sichuan University ( Site 0119), Chengdu, Sichuan, China
Suining Central Hospital ( Site 0857), Suining, Sichuan, China
Tianjin Medical University Cancer Institute & Hospital ( Site 0098), Tianjin, Tianjin Municipality, China
Tianjin Third Central Hospital ( Site 0861), Tianjin, Tianjin Municipality, China
The First Hospital of Kunming ( Site 0124), Kunming, Yunnan, China
2nd Affil Hosp of Zhejiang University College of Medicine ( Site 0110), Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital ( Site 0094), Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital ( Site 0103), Hangzhou, Zhejiang, China
Ningbo Medical Center LiHuili Hospital ( Site 0132), Ningbo, Zhejiang, China
Hospital Pablo Tobon Uribe ( Site 0145), Medellín, Antioquia, Colombia
Administradora Country S.A. ( Site 0137), Bogotá, Bogota D.C., Colombia
Fundacion Cardiovascular de Colombia ( Site 0136), Piedecuesta, Santander Department, Colombia
Fundación Valle del Lili ( Site 0140), Cali, Valle del Cauca Department, Colombia
Herlev Hospital ( Site 0170), Herlev, Capital Region, Denmark
Aarhus Universitets hospital ( Site 0175), Aarhus N, Central Jutland, Denmark
Odense Universitetshospital ( Site 0160), Odense, Region Syddanmark, Denmark
Hopital de la Croix-Rousse ( Site 0193), Lyon, Auvergne, France
Hopital de la Timone ( Site 0188), Marseille, Bouches-du-Rhone, France
CHU Bordeaux Haut-Leveque ( Site 0185), Pessac, Gironde, France
C.H.U. de Nancy. Hopital de Brabois Adultes ( Site 0180), Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France
A.P.H. Paris, Hopital Henri Mondor ( Site 0179), Créteil, Val-de-Marne, France
Hopital Paul Brousse ( Site 0182), Villejuif, Val-de-Marne, France
Universitaetsklinikum Freiburg ( Site 0199), Freiburg im Breisgau, Baden-Wurttemberg, Germany
Krankenhaus Nord-West GmbH ( Site 0208), Frankfurt am Main, Hesse, Germany
Medizinische Hochschule Hannover ( Site 0200), Hanover, Lower Saxony, Germany
Universitaetsklinikum Bonn ( Site 0203), Bonn, North Rhine-Westphalia, Germany
Universitaetsklinikum Leipzig ( Site 0202), Leipzig, Saxony, Germany
Universitaetsklinikum Halle ( Site 0213), Halle, Saxony-Anhalt, Germany
Universitaetsklinikum Schleswig-Holstein-Campus Lubeck ( Site 0215), Lübeck, Schleswig-Holstein, Germany
Charite - Universitaetsmedizin ( Site 0204), Berlin, Germany
Universitaetsklinikum Hamburg-Eppendorf ( Site 0207), Hamburg, Germany
Prince of Wales Hospital ( Site 0242), Shatin, Hong Kong
Somogy Megyei Kaposi Mór Oktató Kórház-Oncology center ( Site 0267), Kaposvár, Somogy County, Hungary
Zala Megyei Szent Rafael Korhaz ( Site 0265), Zalaegerszeg, Zala County, Hungary
Semmelweis University ( Site 0264), Budapest, Hungary
St Vincents University Hospital ( Site 0690), Dublin, Ireland
Emek Medical Center ( Site 0307), Afula, Israel
Rambam Health Care Campus-Oncology Division ( Site 0305), Haifa, Israel
Hadassah Ein Karem Jerusalem ( Site 0303), Jerusaelm, Israel
Rabin Medical Center ( Site 0304), Petah Tikva, Israel
Sourasky Medical Center ( Site 0306), Tel Aviv, Israel
Ospedale del Mare ( Site 0327), Naples, Campania, Italy
ASST Grande Ospedale Metropolitano Niguarda-Oncologia Falck ( Site 0331), Milan, Milano, Italy
Ospedale Mauriziano-SCDU ONCOLOGIA MEDICA ( Site 0333), Turin, Piedmont, Italy
AOU Policlinico G. Martino ( Site 0324), Messina, Sicily, Italy
Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 0334), Brescia, Italy
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico ( Site 0325), Milan, Italy
Az Osp di Rilievo Nazionale A. Cardarelli ( Site 0329), Naples, Italy
Azienda USL della Romagna-Dipartimento di Oncologia ed Ematologia ( Site 0332), Ravenna, Italy
Policlinico Universitario -Agostino Gemelli ( Site 0328), Roma, Italy
National Cancer Center Hospital East ( Site 0347), Kashiwa, Chiba, Japan
Ehime University Hospital ( Site 0368), Tōon, Ehime, Japan
Kurume University Hospital ( Site 0362), Kurume, Fukuoka, Japan
Sapporo Kosei General Hospital ( Site 0345), Sapporo, Hokkaido, Japan
Kanazawa University Hospital ( Site 0354), Kanazawa, Ishikawa-ken, Japan
Kagawa Prefectural Central Hospital ( Site 0364), Takamatsu, Kagawa-ken, Japan
Toranomon Hospital Kajigaya ( Site 0369), Kawasaki, Kanagawa, Japan
Yokohama City University Medical Center ( Site 0351), Yokohama, Kanagawa, Japan
Kanagawa Cancer Center ( Site 0352), Yokohama, Kanagawa, Japan
Nara Medical University Hospital ( Site 0359), Kashihara, Nara, Japan
Kindai University Hospital ( Site 0358), Sayama, Osaka, Japan
Saitama Medical University Hospital ( Site 0370), Iruma-gun, Saitama, Japan
Shizuoka Cancer Center ( Site 0365), Suntogun, Shizuoka, Japan
Jichi Medical University Hospital ( Site 0353), Shimotsuke, Tochigi, Japan
Chiba University Hospital ( Site 0346), Chiba, Japan
National Hospital Organization Kyushu Medical Center ( Site 0361), Fukuoka, Japan
Hiroshima University Hospital ( Site 0360), Hiroshima, Japan
Kumamoto University Hospital ( Site 0372), Kumamoto, Japan
University Hospital,Kyoto Prefectural University of Medicine ( Site 0367), Kyoto, Japan
Osaka International Cancer Institute ( Site 0357), Osaka, Japan
Japanese Red Cross Osaka Hospital ( Site 0356), Osaka, Japan
Saga-Ken Medical Centre Koseikan ( Site 0363), Saga, Japan
Toranomon Hospital ( Site 0349), Tokyo, Japan
Juntendo University Hospital ( Site 0371), Tokyo, Japan
The University of Tokyo Hospital ( Site 0348), Tokyo, Japan
Maastricht University Medical Centre ( Site 0440), Maastricht, Limburg, Netherlands
AMC ( Site 0438), Amsterdam, North Holland, Netherlands
Leids Universitair Medisch Centrum-Medical Oncology ( Site 0442), Leiden, South Holland, Netherlands
Erasmus University Medical Center ( Site 0439), Rotterdam, South Holland, Netherlands
Universitair Medisch Centrum Utrecht-Medical Oncology ( Site 0441), Utrecht, Netherlands
Auckland City Hospital ( Site 0459), Auckland, New Zealand
Oslo Universitetssykehus Ullevål ( Site 0500), Oslo, Norway
Centro Hospitalar e Universitario de Coimbra ( Site 0502), Coimbra, Portugal
Unidade Local de Saude de São José - Hospital de Santo Antonio dos Capuchos ( Site 0505), Lisbon, Portugal
Centro Hospitalar do Porto, E.P.E. - Hospital Geral de Sto. Antonio ( Site 0504), Porto, Portugal
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 0503), Porto, Portugal
Centro Hospitalar de Sao Joao. EPE - Hospital de Sao Joao ( Site 0501), Porto, Portugal
Puerto Rico Medical Research Center LLC ( Site 0523), Hato Rey, Puerto Rico
Ad-Vance Medical Research LLC ( Site 0527), Ponce, Puerto Rico
VA Caribbean Healthcare System ( Site 0524), San Juan, Puerto Rico
FDI Clinical Research ( Site 0522), San Juan, Puerto Rico
Chonnam National University Hwasun Hospital ( Site 0572), Hwasun, Jeonranamdo, South Korea
Seoul National University Bundang Hospital ( Site 0570), Seongnam-si, Kyonggi-do, South Korea
Pusan National University Hospital ( Site 0568), Busan, Pusan-Kwangyokshi, South Korea
Kyungpook National University Hospital ( Site 0569), Daegu, Taegu-Kwangyokshi, South Korea
Seoul National University Hospital ( Site 0567), Seoul, South Korea
Severance Hospital Yonsei University Health System ( Site 0564), Seoul, South Korea
Asan Medical Center ( Site 0565), Seoul, South Korea
Samsung Medical Center ( Site 0566), Seoul, South Korea
The Catholic University of Korea St. Mary s Hospital ( Site 0571), Seoul, South Korea
Korea University Guro Hospital ( Site 0573), Seoul, South Korea
Hospital Universitario Puerta de Hierro ( Site 0596), Majadahonda, Madrid, Spain
Hospital General Universitario de Valencia ( Site 0595), Valencia, Valenciana, Comunitat, Spain
Hospital General Universitario Gregorio Maranon ( Site 0598), Madrid, Spain
Hospital Ramon y Cajal ( Site 0593), Madrid, Spain
Hospital Clinico San Carlos ( Site 0597), Madrid, Spain
Hospital Virgen del Rocio ( Site 0591), Seville, Spain
Chang Gung Medical Foundation. Kaohsiung Branch ( Site 0609), Kaohsiung City, Kaohsiung, Taiwan
Kaohsiung Medical University Hospital ( Site 0611), Kaohsiung City, Taiwan
China Medical University Hospital-Surgical Department ( Site 0610), Taichung, Taiwan
Taichung Veterans General Hospital ( Site 0613), Taichung, Taiwan
National Cheng Kung University Hospital ( Site 0608), Tainan, Taiwan
National Taiwan University Hospital ( Site 0606), Taipei, Taiwan
Taipei Veterans General Hospital-Division of Gastroenterology & Hepatology, Department of Medicine ( Site 0612), Taipei, Taiwan
Chang Gung Medical Foundation. Linkou ( Site 0607), Taoyuan District, Taiwan
Chulalongkorn University ( Site 0627), Bangkok, Bangkok, Thailand
Ramathibodi Hospital, Mahidol University ( Site 0628), Bangkok, Bangkok, Thailand
Faculty of Medicine Siriraj Hospital ( Site 0629), Bangkok, Bangkok, Thailand
Hacettepe University Medical Faculty ( Site 0653), Ankara, Turkey (Türkiye)
Ankara City Hospital-Medical Oncology ( Site 0661), Ankara, Turkey (Türkiye)
Trakya University Medical Faculty Balkan Oncology Hospital ( Site 0648), Edirne, Turkey (Türkiye)
Bezmialem Vakf Üniversitesi-Oncology ( Site 0660), Istanbul, Turkey (Türkiye)
Ege University Medical Faculty Tulay Aktas Oncology Hospital ( Site 0654), Izmir, Turkey (Türkiye)
I.E.U. Medical Point Hastanesi ( Site 0649), Izmir, Turkey (Türkiye)
Konya Necmettin Erbakan University Medical Faculty ( Site 0652), Konya, Turkey (Türkiye)
Inonu Universitesi Medical Fakultesi ( Site 0650), Malatya, Turkey (Türkiye)
Communal non profit enterprise Regional Clinical Oncology Center ( Site 0669), Kharkiv, Kharkivs’ka Oblast’, Ukraine
Barts Health NHS Trust ( Site 0692), London, London, City of, United Kingdom
Royal Marsden NHS Foundation Trust ( Site 0694), London, London, City of, United Kingdom
Royal Marsden NHS Trust ( Site 0693), Sutton, London, City of, United Kingdom

View source on ClinicalTrials.gov